Chronic Myelogenous Leukemia

Authors:
Susan O'Brien
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 MD
,
Ellin Berman
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 MD
,
Hossein Borghaei
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 DO, MS
,
Daniel J. DeAngelo
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 MD, PhD
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Marcel P. Devetten
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 MD
,
Steven Devine
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 MD
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Harry P. Erba
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 MD, PhD
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Jason Gotlib
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 MD, MS
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Madan Jagasia
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 MD
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Joseph O. Moore
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 MD
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Tariq Mughal
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 MD
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Javier Pinilla-Ibarz
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 MD, PhD
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Jerald P. Radich
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 MD
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Neil P. Shah
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 MD, PhD
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Paul J. Shami
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 MD
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B. Douglas Smith
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 MD
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David S. Snyder
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 MD
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Martin S. Tallman
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 MD
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Moshe Talpaz
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 MD
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Meir Wetzler
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 MD
Volume/Issue:
Volume 7: Issue 9
Online Publication Date:
Oct 2009
DOI:
https://doi.org/10.6004/jnccn.2009.0065
Full access
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  • 1

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    Hochhaus A, Druker B, Sawyers C et al.. Favorable long-term follow-up results over 6 years for response, survival, and safety with imatinib mesylate therapy in chronic-phase chronic myeloid leukemia after failure of interferon-alpha treatment. Blood 2008;111:1039–1043.

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    O’Brien SG, Guilhot F, Larson RA et al.. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003;348:994–1004.

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    Druker BJ, Guilhot F, O’Brien SG et al.. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006;355:2408–2417.

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    O’Brien SG, Guilhot F, Goldman JM et al.. International Randomized Study of Interferon Versus STI571 (IRIS) 7-year follow-up: sustained survival, low rate of transformation and increased rate of major molecular response (MMR) in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CMLCP) treated with imatinib (IM) [abstract]. Blood 2008;112:Abstract 186.

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    Kantarjian HM, Talpaz M, O’Brien S et al.. Survival benefit with imatinib mesylate versus interferon-{alpha}-based regimens in newly diagnosed chronic-phase chronic myelogenous leukemia. Blood 2006;108:1835–1840.

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  • 18

    Quintas-Cardama A, Kantarjian H, O’Brien S et al.. Granulocyte-colony-stimulating factor (filgrastim) may overcome imatinib-induced neutropenia in patients with chronic-phase chronic myelogenous leukemia. Cancer 2004;100:2592–2597.

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    Hochhaus A, Kantarjian HM, Baccarani M et al.. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood 2007;109:2303–2309.

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  • 24

    Mauro MJ, Baccarani M, Cervantes F et al.. Dasatinib 2-year efficacy in patients with chronic-phase chronic myelogenous leukemia (CML-CP) with resistance or intolerance to imatinib (START-C) [abstract]. J Clin Oncol 2008;26(Suppl 1):Abstract 7009.

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  • 25

    Baccarani M, Rosti G, Saglio G et al.. Dasatinib time to and durability of major and complete cytogenetic response (MCyR and CCyR) in patients with chronic myeloid leukemia in chronic phase (CML-CP) [abstract]. Blood 2008;112:Abstract 450.

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  • 26

    Guilhot F, Apperley J, Kim DW et al.. Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase. Blood 2007;109:4143–4150.

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  • 27

    Apperley JF, Cortes JE, Kim DW et al.. Dasatinib in the treatment of chronic myeloid leukemia in accelerated phase after imatinib failure: the START A trial. J Clin Oncol 2009;27:3472–3479.

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  • 28

    Kantarjian H, Cortes J, Kim DW et al.. Phase 3 study of dasatinib 140 mg once daily versus 70 mg twice daily in patients with chronic myeloid leukemia in accelerated phase resistant or intolerant to imatinib: 15-month median follow-up. Blood 2009;113:6322–6329.

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  • 29

    Cortes J, Rousselot P, Kim DW et al.. Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis. Blood 2007;109:3207–3213.

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  • 31

    Saglio G, Kantarjian HM, Hochhaus A et al.. Dasatinib 140 mg once daily (QD) demonstrates equivalent efficacy and improved safety compared with 70 mg twice daily (BID) in patients with chronic myeloid leukemia in blast phase (CML-BP): 2-year data from CA180-035 [abstract]. Blood 2008;112:Abstract 3226.

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  • 32

    Quintas-Cardama A, Han X, Kantarjian H, Cortes J. Tyrosine kinase inhibitor-induced platelet dysfunction in patients with chronic myeloid leukemia. Blood 2009;114:261–263.

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  • 33

    Quintas-Cardama A, Kantarjian H, O’Brien S et al.. Pleural effusion in patients with chronic myelogenous leukemia treated with dasatinib after imatinib failure. J Clin Oncol 2007;25:3908–3914.

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  • 34

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  • 37

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  • 38

    Kantarjian HM, Giles F, Gattermann N et al.. Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance. Blood 2007;110:3540–3546.

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  • 39

    Kantarjian H, Giles F, Bhalla K et al.. Nilotinib in chronic myeloid leukemia patients in chronic phase (CML-CP) with imatinib (IM) resistance or intolerance: longer follow-up results of a phase II study [abstract]. J Clin Oncol 2009;27(Suppl 1):Abstract 7029.

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  • 40

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  • 41

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  • 42

    Giles FJ, Larson RA, Kantarjian HM et al.. Nilotinib in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in blast crisis (CML-BC) who are resistant or intolerant to imatinib [abstract]. J Clin Oncol 2008;26(Suppl 1):Abstract 7017.

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    Hughes TP, Branford S, White DL et al.. Impact of early dose intensity on cytogenetic and molecular responses in chronic phase CML patients receiving 600 mg/day of imatinib as initial therapy. Blood 2008;112:3965–3973.

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  • 62

    Aoki E, Kantarjian H, O’Brien S et al.. High-dose (HD) imatinib provides better responses in patients with untreated early chronic phase (CP) CML [abstract]. Blood 2006;108:Abstract 2143.

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  • 63

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Copyright:
Copyright © 2009 by the National Comprehensive Cancer Network 2009
Page Numbers:
40
Article Category:
Research Article
Print Publication Date:
01 Oct 2009
Online Publication Date:
Oct 2009
Keywords:
NCCN Clinical Practice Guidelines; chronic myelogenous leukemia; karyotyping; transplantation; imatinib; dasatinib; nilotinib; allogenic HSCT; hematologic response; cytogenetic response
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