• 1

    Jemal A, Siegel R, Ward E et al. . Cancer statistics, 2009. CA Cancer J Clin 2009;59:225229.

  • 2

    Bonelli L, Martines H, Conio M et al. . Family history of colorectal cancer as a risk factor for benign and malignant tumours of the large bowel. A case-control study. Int J Cancer 1988;41:513517.

    • Search Google Scholar
    • Export Citation
  • 3

    Ahsan H, Neugut AI, Garbowski GC et al. . Family history of colorectal adenomatous polyps and increased risk for colorectal cancer. Ann Intern Med 1998;128:900905.

    • Search Google Scholar
    • Export Citation
  • 4

    Greene F, Page D, Fleming I, Fritz A. AJCC Cancer Staging Manual. New York: Springer-Verlag; 2002.

  • 5

    Compton CC, Greene FL. The staging of colorectal cancer: 2004 and beyond. CA Cancer J Clin 2004;54:295308.

  • 6

    Greene FL, Stewart AK, Norton HJ. A new TNM staging strategy for node-positive (stage III) colon cancer: an analysis of 50,042 patients. Ann Surg 2002;236:416421; discussion 421.

    • Search Google Scholar
    • Export Citation
  • 7

    Compton CC. Updated protocol for the examination of specimens from patients with carcinomas of the colon and rectum, excluding carcinoid tumors, lymphomas, sarcomas, and tumors of the vermiform appendix: a basis for checklists. Cancer Committee. Arch Pathol Lab Med 2000;124:10161025.

    • Search Google Scholar
    • Export Citation
  • 8

    Compton CC. Key issues in reporting common cancer specimens: problems in pathologic staging of colon cancer. Arch Pathol Lab Med 2006;130:318324.

    • Search Google Scholar
    • Export Citation
  • 9

    Lai LL, Fuller CD, Kachnic LA, Thomas CR Jr. Can pelvic radiotherapy be omitted in select patients with rectal cancer? Semin Oncol 2006;33(Suppl 11):S70–74.

    • Search Google Scholar
    • Export Citation
  • 10

    Nagtegaal ID, Marijnen CA, Kranenbarg EK et al. . Circumferential margin involvement is still an important predictor of local recurrence in rectal carcinoma: not one millimeter but two millimeters is the limit. Am J Surg Pathol 2002;26:350357.

    • Search Google Scholar
    • Export Citation
  • 11

    Wibe A, Rendedal PR, Svensson E et al. . Prognostic significance of the circumferential resection margin following total mesorectal excision for rectal cancer. Br J Surg 2002;89:327334.

    • Search Google Scholar
    • Export Citation
  • 12

    Stocchi L, Nelson H, Sargent DJ et al. . Impact of surgical and pathologic variables in rectal cancer: a United States community and cooperative group report. J Clin Oncol 2001;19:38953902.

    • Search Google Scholar
    • Export Citation
  • 13

    Glynne-Jones R, Mawdsley S, Novell JR. The clinical significance of the circumferential resection margin following preoperative pelvic chemo-radiotherapy in rectal cancer: why we need a common language. Colorectal Dis 2006;8:800807.

    • Search Google Scholar
    • Export Citation
  • 14

    Adam IJ, Mohamdee MO, Martin IG et al. . Role of circumferential margin involvement in the local recurrence of rectal cancer. Lancet 1994;344:707711.

    • Search Google Scholar
    • Export Citation
  • 15

    Mawdsley S, Glynne-Jones R, Grainger J et al. . Can histopathologic assessment of circumferential margin after preoperative pelvic chemoradiotherapy for T3-T4 rectal cancer predict for 3-year disease-free survival? Int J Radiat Oncol Biol Phys 2005;63:745752.

    • Search Google Scholar
    • Export Citation
  • 16

    Nagtegaal ID, Quirke P. What is the role for the circumferential margin in the modern treatment of rectal cancer? J Clin Oncol 2008;26:303312.

    • Search Google Scholar
    • Export Citation
  • 17

    Sarli L, Bader G, Iusco D et al. . Number of lymph nodes examined and prognosis of TNM stage II colorectal cancer. Eur J Cancer 2005;41:272279.

  • 18

    Newland RC, Dent OF, Lyttle MN et al. . Pathologic determinants of survival associated with colorectal cancer with lymph node metastases. A multivariate analysis of 579 patients. Cancer 1994;73:20762082.

    • Search Google Scholar
    • Export Citation
  • 19

    Wong SL, Hong J, Hollenbeck BK et al. . Hospital lymph node examination rates and survival after resection for colon cancer. JAMA 2007;298:21492154.

    • Search Google Scholar
    • Export Citation
  • 20

    Tepper JE, O’Connell MJ, Niedzwiecki D et al. . Impact of number of nodes retrieved on outcome in patients with rectal cancer. J Clin Oncol 2001;19:157163.

    • Search Google Scholar
    • Export Citation
  • 21

    Pocard M, Panis Y, Malassagne B et al. . Assessing the effectiveness of mesorectal excision in rectal cancer: prognostic value of the number of lymph nodes found in resected specimens. Dis Colon Rectum 1998;41:839845.

    • Search Google Scholar
    • Export Citation
  • 22

    Wichmann MW, Muller C, Meyer G et al. . Effect of preoperative radiochemotherapy on lymph node retrieval after resection of rectal cancer. Arch Surg 2002;137:206210.

    • Search Google Scholar
    • Export Citation
  • 23

    Baxter NN, Morris AM, Rothenberger DA, Teppe JE. Impact of pre-operative radiation for rectal cancer on subsequent lymph node evaluation: population based analysis. Int J Rad Oncol Biol Phys 2005;61:426431.

    • Search Google Scholar
    • Export Citation
  • 24

    Meyers MO, Hollis DR, Mayer RJ et al. . Ratio of metastatic to examined lymph nodes is a powerful predictor of overall survival in rectal cancer: an analysis of Intergroup 0114 [abstract]. J Clin Oncol 2007;25(Suppl 1):Abstract 4008.

    • Search Google Scholar
    • Export Citation
  • 25

    Turner RR, Nora DT, Trocha SD, Bilchik AJ. Colorectal carcinoma nodal staging. Frequency and nature of cytokeratin-positive cells in sentinel and nonsentinel lymph nodes. Arch Pathol Lab Med 2003;127:673679.

    • Search Google Scholar
    • Export Citation
  • 26

    Wood TF, Nora DT, Morton DL et al. . One hundred consecutive cases of sentinel node mapping in early colorectal carcinoma. Detection of micrometastasis. J Gastrointest Surg 2002;6:322330.

    • Search Google Scholar
    • Export Citation
  • 27

    Noura S, Yamamoto H, Miyake Y et al. . Immunohistochemical assessment of localization and frequency of micrometastases in lymph nodes of colorectal cancer. Clin Cancer Res 2002;8:759767.

    • Search Google Scholar
    • Export Citation
  • 28

    Yasuda K, Adachi Y, Shiraishi N et al. . Pattern of lymph node micrometastasis and prognosis of patients with colorectal cancer. Ann Surg Oncol 2001;8:300304.

    • Search Google Scholar
    • Export Citation
  • 29

    Braat AE, Oosterhuis JW, Moll FC et al. . Sentinel node detection after preoperative short-course radiotherapy in rectal carcinoma is not reliable. Br J Surg 2005;92:15331538.

    • Search Google Scholar
    • Export Citation
  • 30

    Baselga J, Rosen N. Determinants of RASistance to anti-epidermal growth factor receptor agents. J Clin Oncol 2008;26:15821584.

  • 31

    Amado RG, Wolf M, Peeters M et al. . Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008;26:16261634.

    • Search Google Scholar
    • Export Citation
  • 32

    Khambata-Ford S, Garrett CR, Meropol NJ et al. . Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol 2007;25:32303237.

    • Search Google Scholar
    • Export Citation
  • 33

    De Roock W, Piessevaux H, De Schutter J et al. . KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann Oncol 2008;19:508515.

    • Search Google Scholar
    • Export Citation
  • 34

    Punt CJ, Tol J, Rodenburg CJ et al. . Randomized phase III study of capecitabine, oxaliplatin, and bevacizumab with or without cetuximab in advanced colorectal cancer, the CAIRO2 study of the Dutch Colorectal Cancer Group [abstract]. J Clin Oncol 2008;26(Suppl 1):Abstract LBA 4011.

    • Search Google Scholar
    • Export Citation
  • 35

    Bokemeyer C, Bondarenko I, Makhson A et al. . Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 2009;27:663771.

    • Search Google Scholar
    • Export Citation
  • 36

    Tejpar S, Peeters M, Humblet Y et al. . Relationship of efficacy with KRAS status (wild type versus mutant) in patients with irinotecan-refractory metastatic colorectal cancer, treated with irinotecan and escalating doses of cetuximab: the EVEREST experience (preliminary data) [abstract]. J Clin Oncol 2008;26(Suppl 1):Abstract 4001.

    • Search Google Scholar
    • Export Citation
  • 37

    Van Cutsem E, Henning-Kohne C, Hitre E et al. . Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009; 36014:14081417.

    • Search Google Scholar
    • Export Citation
  • 38

    Lièvre A, Bachet JB, Boige V et al. . KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol 2008;26:374379.

    • Search Google Scholar
    • Export Citation
  • 39

    Karapetis CS, Khambata-Ford S, Jonker DJ et al. . K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008;359:17571765.

    • Search Google Scholar
    • Export Citation
  • 40

    Lievre A, Bachet JB, Boige V et al. . KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treatment with cetuximab. J Clin Oncol 2008;26:374379.

    • Search Google Scholar
    • Export Citation
  • 41

    Artale S, Sartore-Bianchi A, Veronese SM et al. . Mutations in KRAS and BRAF in primary and matched metastatic sites of colorectal cancer. J Clin Oncol 2008;26:42174219.

    • Search Google Scholar
    • Export Citation
  • 42

    Etienne-Grimaldi MC, Formento JL, Francoual M et al. . KRAS mutations in treatment outcome in colorectal cancer in patients receiving exclusive fluoropyrimidine. Clin Cancer Res 2008;14:48304835.

    • Search Google Scholar
    • Export Citation
  • 50

    Nelson H, Petrelli N, Carlin A et al. . Guidelines 2000 for colon and rectal cancer surgery. J Natl Cancer Inst 2001;93:583596.

  • 51

    Kapiteijn E, Marijnen CA, Nagtegaal ID et al. . Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001;345:638646.

    • Search Google Scholar
    • Export Citation
  • 52

    Schoellhammer HF, Gregorian AC, Sarkisyan GG, Petrie BA. How important is rigid proctosigmoidoscopy in localizing rectal cancer. Am J Surg 2008;186:904908.

    • Search Google Scholar
    • Export Citation
  • 53

    Baxter NN, Garcia-Aguilar J. Organ preservation for rectal cancer. J Clin Oncol 2007;25:10141020.

  • 54

    Weiser MR, Landmann RG, Wong WD et al. . Surgical salvage of recurrent rectal cancer after transanal excision. Dis Colon Rectum 2005;48:11691175.

  • 55

    Wiig JN, Larsen SG, Giercksky KE. Operative treatment of locally recurrent rectal cancer. Recent Results Cancer Res 2005;165:136147.

  • 56

    Bartram C, Brown G. Endorectal ultrasound and magnetic resonance imaging in rectal cancer staging. Gastroenterol Clin North Am 2002;31:827839.

    • Search Google Scholar
    • Export Citation
  • 57

    Bipat S, Glas AS, Slors FJ et al. . Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging—a meta-analysis. Radiology 2004;232:773783.

    • Search Google Scholar
    • Export Citation
  • 58

    Klessen C, Rogalla P, Taupitz M. Local staging of rectal cancer: the current role of MRI. Eur Radiol 2007;17:379389.

  • 59

    Lahaye MJ, Engelen SM, Nelemans PJ et al. . Imaging for predicting the risk factors—the circumferential resection margin and nodal disease—of local recurrence in rectal cancer: a meta-analysis. Semin Ultrasound CT MR 2005;26:259268.

    • Search Google Scholar
    • Export Citation
  • 60

    Beets-Tan RG, Vliegen RF, Beets GL. Magnetic resonance imaging of rectal cancer: what radiation oncologists need to know. Front Radiat Ther Oncol 2004;38:112.

    • Search Google Scholar
    • Export Citation
  • 61

    Guillem JG, Cohen AM. Current issues in colorectal cancer surgery. Semin Oncol 1999;26:505513.

  • 62

    You YN, Baxter NN, Stewart A, Nelson H. Is the increasing rate of local excision for stage I rectal cancer in the United States justified?: a nationwide cohort study from the National Cancer Database. Ann Surg 2007;245:726733.

    • Search Google Scholar
    • Export Citation
  • 63

    Landmann RG, Wong WD, Hoepfl J et al. . Limitations of early rectal cancer nodal staging may explain failure after local excision. Dis Colon Rectum 2007;50:15201525.

    • Search Google Scholar
    • Export Citation
  • 64

    Nash GM, Weiser MR, Guillem JG et al. . Long-term survival after transanal excision of T1 rectal cancer. Dis Colon Rectum 2009;52:577582.

  • 65

    Jayne DG, Guillou, Thorpe H et al. . Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC trial group. J Clin Oncol 2007;25:30613068.

    • Search Google Scholar
    • Export Citation
  • 66

    Ng SS, Leung KL, Lee JF et al. . Laparoscopic-assisted versus open abdominoperineal resection for low rectal cancer: a prospective randomized trial. Ann Surg Oncol 2008;15:24182425.

    • Search Google Scholar
    • Export Citation
  • 67

    Wagman LJ. Laparoscopic and open surgery for colorectal cancer: reaching equipoise? J Clin Oncol 2007;25:29962998.

  • 68

    Heald RJ, Husband EM, Ryall RD. The mesorectum in rectal cancer surgery—the clue to pelvic recurrence? Br J Surg 1982;69:613616.

  • 69

    Parfitt JR, Driman DK. The total mesorectal excision specimen for rectal cancer: a review of its pathological assessment. J Clin Pathol 2007;60:849855.

    • Search Google Scholar
    • Export Citation
  • 70

    Nagetgaal ID, van de Velde CJH, van der Worp E et al. . Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control. J Clin Oncol 2002;20:17291734.

    • Search Google Scholar
    • Export Citation
  • 71

    Marr R, Birbeck K, Garvican J et al. . The modern abdominoperineal excision: the next challenge after total mesorectal excision. Ann Surg 2005;242:7482.

    • Search Google Scholar
    • Export Citation
  • 72

    Pahlman L, Bohe M, Cedermark B et al. . The Swedish rectal cancer registry. Br J Surg 2007;94:12851292.

  • 73

    den Dulk M, Putter H, Collette L et al. . The abdominoperineal resection itself is associated with an adverse outcome: the European experience based on a pooled analysis of five European randomised clinical trials on rectal cancer. Eur J Cancer 2009;45:11751183.

    • Search Google Scholar
    • Export Citation
  • 74

    Steup WH, Moriya Y, van de velde CJH. Patterns of lymphatic spread in rectal cancer. A topographical analysis on lymph node metastases. Eur J Cancer 2002;38:911918.

    • Search Google Scholar
    • Export Citation
  • 75

    Schlag PM. Surgical sphincter preservation in rectal cancer. Oncologist 1996;1:288292.

  • 76

    Wagman R, Minsky BD, Cohen AM et al. . Sphincter preservation in rectal cancer with preoperative radiation therapy and coloanal anastomosis: long term follow-up. Int J Radiat Oncol Biol Phys 1998;42:5157.

    • Search Google Scholar
    • Export Citation
  • 77

    Sauer R, Becker H, Hohenberger W et al. . Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004;351:17311740.

  • 78

    Kachnic LA. Should preoperative or postoperative therapy be administered in the management of rectal cancer? Semin Oncol 2006;33(Suppl 11):S6469.

    • Search Google Scholar
    • Export Citation
  • 79

    Madoff RD. Chemoradiotherapy for rectal cancer—when, why, and how? N Engl J Med 2004;351:17901792.

  • 80

    Guillem JG, Diaz-Gonzolez JA, Minsky B et al. . cT3N0 rectal cancer: potential overtreatment with preoperative chemoradiotherapy is warranted. J Clin Oncol 2008;26:368373.

    • Search Google Scholar
    • Export Citation
  • 81

    Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Trial. N Engl J Med 1997;336:980987.

    • Search Google Scholar
    • Export Citation
  • 82

    Colorectal Collaborative Group. Adjuvant radiotherapy for rectal cancer: a systematic overview of 8,507 patients from 22 randomised trials. Lancet 2001;358:12911304.

    • Search Google Scholar
    • Export Citation
  • 83

    Peeters KCMJ, Marijnen CAM, Nagtegaal ID et al. . The TME trial after a median follow-up of 6 years. Ann Surg 2007;246:693701.

  • 84

    Sebag-Montefiore D, Stephens RJ, Steele R et al. . Prooperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet 2009;373:811820.

    • Search Google Scholar
    • Export Citation
  • 85

    Gerard JP, Conroy T, Bonnetain F et al. . Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203. J Clin Oncol 2006;24:46204625.

    • Search Google Scholar
    • Export Citation
  • 86

    Ceelen WP, van Nieuwenhove Y, Fierens K. Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer (review). Cochrane Database Syst Rev 2009;CD006041.

    • Search Google Scholar
    • Export Citation
  • 87

    Glynne-Jones R, Sebag-Montefiore D. Role of neoadjuvant chemotherapy in rectal cancer: interpretation of the EXPERT study. J Clin Oncol 2006;24:46644665; author reply 4665–4666.

    • Search Google Scholar
    • Export Citation
  • 88

    Bosset JF, Calais G, Mineur L et al. . Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results—EORTC 22921. J Clin Oncol 2005;23:56205627.

    • Search Google Scholar
    • Export Citation
  • 89

    Bosset JF, Collette L, Calais G et al. . Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 2006;355:11141123.

  • 90

    Collette L, Bosset JF, den Dulk M et al. . Patients with curative resection of cT3-4 rectal cancer after preoperative radiotherapy or radiochemotherapy: does anybody benefit from adjuvant fluorouracil-based chemotherapy? A trial of the EORTC Group. J Clin Oncol 2007;25:43794386.

    • Search Google Scholar
    • Export Citation
  • 91

    Bujko K, Kepka L, Michalski W, Nowacki MP. Does rectal cancer shrinkage induced by preoperative radio(chemo)therapy increase the likelihood of anterior resection? A systematic review of randomised trials. Radiother Oncol 2006;80:412.

    • Search Google Scholar
    • Export Citation
  • 92

    Wong RK, Tandan V, De Silva S, Figueredo A. Pre-operative radiotherapy and curative surgery for the management of localized rectal carcinoma. Cochrane Database Syst Rev 2007:CD002102.

    • Search Google Scholar
    • Export Citation
  • 93

    Peeters KC, van de Velde CJ, Leer JW et al. . Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients—a Dutch colorectal cancer group study. J Clin Oncol 2005;23:61996206.

    • Search Google Scholar
    • Export Citation
  • 94

    Tepper JE, O’Connell M, Niedzwiecki D et al. . Adjuvant therapy in rectal cancer: analysis of stage, sex, and local control—final report of intergroup 0114. J Clin Oncol 2002;20:17441750.

    • Search Google Scholar
    • Export Citation
  • 95

    Gunderson LL, Sargent DJ, Tepper JE et al. . Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: a pooled analysis. J Clin Oncol 2004;22:17851796.

    • Search Google Scholar
    • Export Citation
  • 96

    Johal BS, Phang P, McGahan C et al. . Treatment patterns and outcomes of patients with pT3N0 rectal cancer in a population-based setting [abstract]. J Clin Oncol 2007;25(Suppl 1):Abstract 4039.

    • Search Google Scholar
    • Export Citation
  • 97

    Smalley SR, Benedetti JK, Williamson SK et al. . Phase III trial of fluorouracil-based chemotherapy regimens plus radiotherapy in postoperative adjuvant rectal cancer: GI INT 0144. J Clin Oncol 2006;24:35423547.

    • Search Google Scholar
    • Export Citation
  • 98

    O’Connell MJ, Martenson JA, Wieand HS et al. . Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med 1994;331:502507.

    • Search Google Scholar
    • Export Citation
  • 99

    Andre T, Boni C, Navarro et al. . Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC Trial. J Clin Oncol 2009;27:31093116.

    • Search Google Scholar
    • Export Citation
  • 100

    Twelves C, Wong A, Nowacki MP et al. . Capecitabine as adjuvant treatment for stage III colon cancer. N Engl J Med 2005;352:26962704.

  • 101

    Hong TS, Ritter MA, Tome WA, Harari PM. Intensity-modulated radiation therapy: emerging cancer treatment technology. Br J Cancer 2005;92:18191824.

    • Search Google Scholar
    • Export Citation
  • 102

    Meyer J, Czito B, Yin FF, Willett C. Advanced radiation therapy technologies in the treatment of rectal and anal cancer: intensity-modulated photon therapy and proton therapy. Clin Colorectal Cancer 2007;6:348356.

    • Search Google Scholar
    • Export Citation
  • 103

    American College of Radiology. Practice Guideline for Intensity-modulated radiation therapy (IMRT), 2007; Available at: http://www.acr.org/SecondaryMainMenuCategories/quality_safety/guidelines/ro/imrt.aspx. Accessed July 2009

    • Search Google Scholar
    • Export Citation
  • 104

    Valenti V, Balducci M, Tororeto F et al. . Intraoperative radiotherapy: current thinking. Eur J Surg Oncol 2002;28:180185.

  • 105

    Hahnloser D, Haddock MG, Nelson H. Intraoperative radiotherapy in the multimodality approach to colorectal cancer. Surg Oncol Clin N Am 2003;12:9931013.

    • Search Google Scholar
    • Export Citation
  • 106

    Willett CG, Czito BG, Tyler DS. Intraoperative radiation therapy. J Clin Oncol 2007;25:971977.

  • 107

    Moore HG, Gittleman AE, Minsky BD et al. . Rate of pathologic complete response with increased interval between preoperative combined modality therapy and rectal cancer resection. Dis Colon Rectum 2004;47:279286.

    • Search Google Scholar
    • Export Citation
  • 108

    Habr-Gama A, Perez RO, Proscurshim I et al. . Interval between surgery and neoadjuvant chemoradiation therapy for distal rectal cancer: does delayed surgery have an impact on outcome? Int J Radiat Oncol Biol Phys 2008;71:11811188.

    • Search Google Scholar
    • Export Citation
  • 109

    Tulchinsky H, Shmuell E, Giger A et al. . An interval > 7 weeks between neoadjuvant theapy and surgery improves pathologic complete response and disease-free survival in patients with locally advanced rectal cancer. Ann Surg Oncol 2008;15:26612667.

    • Search Google Scholar
    • Export Citation
  • 110

    Tran CL, Udani S, Holt A, Arnell T et al. . Evaluation of safety of increased time interval between chemoradiation and resection for rectal cancer. Am J Surg 2006;192:873877.

    • Search Google Scholar
    • Export Citation
  • 111

    Wolmark N, Wieand HS, Hyams DM et al. . Randomized trial of postoperative adjuvant chemotherapy with or without radiotherapy for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02. J Natl Cancer Inst 2000;92:388396.

    • Search Google Scholar
    • Export Citation
  • 112

    Benson AB III. New approaches to the adjuvant therapy of colon cancer. Oncologist 2006;11:973980.

  • 113

    Minsky BD, Guillem JG. Multidisciplinary management of resectable rectal cancer: new developments and controversies. Oncology (Williston Park) 2008;22:14301437.

    • Search Google Scholar
    • Export Citation
  • 114

    Fakih M. Treating rectal cancer: key issues reconsidered. Oncology (Williston Park) 2008;22:14441446.

  • 115

    Benson AB III. New approaches to assessing and treating early-stage colon and rectal cancers: cooperative group strategies for assessing optimal approaches in early-stage disease. Clin Cancer Res 2007;13:6913s6920s.

    • Search Google Scholar
    • Export Citation
  • 116

    Sengupta S, Tjandra JJ. Local excision of rectal cancer: what is the evidence? Dis Colon Rectum 2001;44:13451361.

  • 117

    Garcia-Aguilar J, Mellgren A, Sirivongs P et al. . Local excision of rectal cancer without adjuvant therapy: a word of caution. Ann Surg 2000;231:345351.

    • Search Google Scholar
    • Export Citation
  • 118

    Willett CG, Compton CC, Shellito PC, Efird JT. Selection factors for local excision or abdominoperineal resection of early stage rectal cancer. Cancer 1994;73:27162720.

    • Search Google Scholar
    • Export Citation
  • 119

    Van Cutsem E, Nordlinger B, Adam R et al. . Towards a pan-European consensus on the treatment of patients with colorectal liver metastases. Eur J Cancer 2006;42:22122221.

    • Search Google Scholar
    • Export Citation
  • 120

    Yoo PS, Lopez-Soler RI, Longo WE, Cha CH. Liver resection for metastatic colorectal cancer in the age of neoadjuvant chemotherapy and bevacizumab. Clin Colorectal Cancer 2006;6:202207.

    • Search Google Scholar
    • Export Citation
  • 121

    Kemeny N. Management of liver metastases from colorectal cancer. Oncology (Williston Park) 2006;20:11611176, 1179.

  • 122

    Muratore A, Zorzi D, Bouzari H et al. . Asymptomatic colorectal cancer with un-resectable liver metastases: immediate colorectal resection or up-front systemic chemotherapy? Ann Surg Oncol 2007;14:766770.

    • Search Google Scholar
    • Export Citation
  • 123

    Alberts SR, Horvath WL, Sternfeld WC et al. . Oxaliplatin, fluorouracil, and leucovorin for patients with unresectable liver-only metastases from colorectal cancer: a North Central Cancer Treatment Group phase II study. J Clin Oncol 2005;23:92439249.

    • Search Google Scholar
    • Export Citation
  • 124

    Fong Y, Cohen AM, Fortner JG et al. . Liver resection for colorectal metastases. J Clin Oncol 1997;15:938946.

  • 125

    Tsai M, Su Y, Ho M et al. . Clinicopathological features and prognosis in resectable synchronous and metachronous colorectal liver metastases. Ann Surg Oncol 2007;14:786794.

    • Search Google Scholar
    • Export Citation
  • 126

    Poultsides GA, Servais EL, Saltz LB et al. . Outcome of primary tumor in patients with synchronous stage IV colorectal cancer receiving combination chemotherapy without surgery as initial treatment. J Clin Oncol 2009;27:33793384.

    • Search Google Scholar
    • Export Citation
  • 127

    Foster JH. Treatment of metastatic disease of the liver: a skeptic’s view. Semin Liver Dis 1984;4:170179.

  • 128

    Stangl R, Altendorf-Hofmann A, Charnley RM, Scheele J. Factors influencing the natural history of colorectal liver metastases. Lancet 1994;343:14051410.

    • Search Google Scholar
    • Export Citation
  • 129

    Venook AP. The Kemeny article reviewed. Oncology 2006;20:477484.

  • 130

    Choti MA, Sitzmann JV, Tiburi MF et al. . Trends in long-term survival following liver resection for hepatic colorectal metastases. Ann Surg 2002;235:759766.

    • Search Google Scholar
    • Export Citation
  • 131

    Pawlik TM, Poon RT, Abdalla EK et al. . Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma. Arch Surg 2005;140:450457; discussion 457–458.

    • Search Google Scholar
    • Export Citation
  • 132

    Charnsangavej C, Clary B, Fong Y et al. . Selection of patients for resection of hepatic colorectal metastases: expert consensus statement. Ann Surg Oncol 2006;13:12611268.

    • Search Google Scholar
    • Export Citation
  • 133

    Vauthey JN, Zorzi D, Pawlik TM. Making unresectable hepatic colorectal metastases resectable—does it work? Semin Oncol 2005;32(Suppl 9):S118122.

    • Search Google Scholar
    • Export Citation
  • 134

    Pozzo C, Basso M, Cassano A et al. . Neoadjuvant treatment of unresectable liver disease with irinotecan and 5-fluorouracil plus folinic acid in colorectal cancer patients. Ann Oncol 2004;15:933939.

    • Search Google Scholar
    • Export Citation
  • 135

    Altendorf-Hofmann A, Scheele J. A critical review of the major indicators of prognosis after resection of hepatic metastases from colorectal carcinoma. Surg Oncol Clin N Am 2003;12:165192.

    • Search Google Scholar
    • Export Citation
  • 136

    Pawlik TM, Schulick RD, Choti MA. Expanding criteria for resectability of colorectal liver metastases. Oncologist 2008;13:5164.

  • 137

    Folprecht G, Grothey A, Alberts S et al. . Neoadjuvant treatment of unresectable colorectal liver metastases: correlation between tumour response and resection rates. Ann Oncol 2005;16:13111319.

    • Search Google Scholar
    • Export Citation
  • 138

    Reddy SK, Pawlik TM, Zorzi D et al. . Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis. Ann Surg Oncol 2007;14:34813491.

    • Search Google Scholar
    • Export Citation
  • 139

    Covey AM, Brown KT, Jarnagin WR et al. . Combined portal vein embolization and neoadjuvant chemotherapy as a treatment strategy for resectable hepatic colorectal metastases. Ann Surg 2008;247:451455.

    • Search Google Scholar
    • Export Citation
  • 140

    Adam R, Miller R, Pitombo M et al. . Two-stage hepatectomy approach for initially unresectable colorectal hepatic metastases. Surg Oncol Clin N Am 2007;16:525536.

    • Search Google Scholar
    • Export Citation
  • 141

    Abdalla EK. Commentary: radiofrequency ablation for colorectal liver metastases: do not blame the biology when it is the technology. Am J Surg 2009;197:737739.

    • Search Google Scholar
    • Export Citation
  • 142

    Abdalla EK, Vauthey JN, Ellis LM et al. . Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg 2004;239:818825.

    • Search Google Scholar
    • Export Citation
  • 143

    Hur H, Ko YT, Min BS et al. . Comparative study of resection and radiofrequency ablation in the treatment of solitary colorectal liver metastases. Am J Surg 2009;197:728736.

    • Search Google Scholar
    • Export Citation
  • 144

    Gleisner AL, Choti MA, Assumpcao L et al. . Colorectal liver metastases: recurrence and survival following hepatic resectin, radiofrequency ablation, and combined resection-radiofrequency ablation. Arch Surg 2008;143:12041212.

    • Search Google Scholar
    • Export Citation
  • 145

    Reuter NP, Woodall CE, Scoggins CR et al. . Radiofrequency ablation vs. resection for hepatic colorectal metastasis: therapeutically equivalent? J Gastrointest Surg 2009;13:486491.

    • Search Google Scholar
    • Export Citation
  • 146

    Leonard GD, Brenner B, Kemeny NE. Neoadjuvant chemotherapy before liver resection for patients with unresectable liver metastases from colorectal carcinoma. J Clin Oncol 2005;23:20382048.

    • Search Google Scholar
    • Export Citation
  • 147

    Benoist S, Brouquet A, Penna C et al. . Complete response of colorectal liver metastases after chemotherapy: does it mean cure? J Clin Oncol 2006;24:39393945.

    • Search Google Scholar
    • Export Citation
  • 148

    Bilchik AJ, Poston G, Curley SA et al. . Neoadjuvant chemotherapy for metastatic colon cancer: a cautionary note. J Clin Oncol 2005;23:90739078.

  • 149

    Adam R, Avisar E, Ariche A et al. . Five-year survival following hepatic resecton after neoadjuvant therapy for nonresectable colorectal cancer. Ann Surg Oncol 2001;8:347353.

    • Search Google Scholar
    • Export Citation
  • 150

    Rivoire M, De Cian F, Meeus P et al. . Combination of neoadjuvant chemotherapy with cryotherapy and surgical resection for the treatment of unresectable liver metastases from colorectal carcinoma. Cancer 2002;95:22832292.

    • Search Google Scholar
    • Export Citation
  • 151

    Vauthey JN, Pawlik TM, Ribero D et al. . Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol 2006;24:20652072.

    • Search Google Scholar
    • Export Citation
  • 152

    Pawlik TM, Olino K, Gleisner AL et al. . Preoperative chemotheapy for colorectal liver metastases: impact on hepatic histology and postoperative outcome. J Gastrointest Surg 2007;11:860888.

    • Search Google Scholar
    • Export Citation
  • 153

    Pawlik TM, Scoggins CR, Zorzi D et al. . Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases. Ann Surg 2005;241:715722.

    • Search Google Scholar
    • Export Citation
  • 154

    Elias D, Liberale G, Vernerey D et al. . Hepatic and extrahepatic colorectal metastases: when resectable, their localization does not matter, but their total number has a prognostic effect. Ann Surg Oncol 2005;12:900909.

    • Search Google Scholar
    • Export Citation
  • 155

    Fong Y, Salo J. Surgical therapy of hepatic colorectal metastasis. Semin Oncol 1999;26:514523.

  • 156

    Adam R, Delvart V, Pascal G et al. . Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival. Ann Surg 2004;240:644657.

    • Search Google Scholar
    • Export Citation
  • 157

    Delaunoit T, Alberts SR, Sargent DJ et al. . Chemotherapy permits resection of metastatic colorectal cancer: experience from Intergroup N9741. Ann Oncol 2005;16:425429.

    • Search Google Scholar
    • Export Citation
  • 158

    Nordlinger B, Sorbye H, Glimelius B et al. . Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomized controlled trial. Lancet 2008;37:10071016.

    • Search Google Scholar
    • Export Citation
  • 159

    Tan BR, Zubal B, Hawkins w et al. . Preoperative FOLFOX plus cetuximab or panitumumab therapy for patients with potentially resectable hepatic colorectal metastases [abstract]. Prestented at the 2009 ASCO Gastrointestinal Cancers Symposium; January 15–17, 2009; San Francisco, California. Abstract 497.

    • Search Google Scholar
    • Export Citation
  • 160

    Folprecht G, Gruenberger T, Hartmann JT et al. . Cetuximab plus FOLFOX6 or cetuximab plus FOLFIRI as neoadjuvant treatment of nonresectable colorectal liver metastases: A randomized multicenter study (CELIM-study) [abstract]. Presented at the 2009 ASCO Gastrointestinal Cancers Symposium; January 15–17 2009; San Francisco, California. Abstract 296.

    • Search Google Scholar
    • Export Citation
  • 161

    Souglakos J, Androulakis N, Syrigos K et al. . FOLFOXIRI vs FOLFIRI as first-line treatment in metastatic colorectal cancer: a multicentre randomised phase III trial from the Hellenic Oncology Research Group. Br J Cancer 2006;94:798805.

    • Search Google Scholar
    • Export Citation
  • 162

    Falcone A, Ricci S, Brunetti I et al. . Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J Clin Oncol 2007;25:16701676.

    • Search Google Scholar
    • Export Citation
  • 163

    Scappaticci FA, Fehrenbacher L, Cartwright T et al. . Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab. J Surg Oncol 2005;91:173180.

    • Search Google Scholar
    • Export Citation
  • 164

    Package Insert. Bevacizumab. South San Francisco, CA, Genentech, Inc. October 2006.

  • 165

    Gruenberger B, Tamandl D, Schueller J et al. . Bevacizumab, capecitabine, and oxaliplatin as neoadjuvant therapy for patients with potentially curable metastatic colorectal cancer. J Clin Oncol 2008;26:18301835.

    • Search Google Scholar
    • Export Citation
  • 166

    Reddy SK, Morse MA, Hurwitz HI et al. . Addition of bevacizumab to irinotecan- and oxaliplatin-based preoperative chemotherapy regimens does not increase morbidity after resection of colorectal liver metastases. J Am Coll Surg 2008;206:96106.

    • Search Google Scholar
    • Export Citation
  • 167

    Lee WS, Yun SH, Chun HK et al. . Pulmonary resection for metastases from colorectal cancer: prognostic factors and survival. Int J Colorectal Dis 2007;22:699704.

    • Search Google Scholar
    • Export Citation
  • 168

    Headrick JR, Miller DL, Nagorney DM et al. . Surgical treatment of hepatic and pulmonary metastases from colon cancer. Ann Thorac Surg 2001;71:975979; discussion 979–980.

    • Search Google Scholar
    • Export Citation
  • 169

    Kemeny N. Management of liver metastases from colorectal cancer. Oncology (Williston Park) 2006;20:11611176, 1179.

  • 170

    Kemeny N, Huang Y, Cohen AM et al. . Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer. N Engl J Med 1999;341:20392048.

    • Search Google Scholar
    • Export Citation
  • 171

    Kemeny NE, Gonen M. Hepatic arterial infusion after liver resection. N Engl J Med 2005;352:7:734735.

  • 172

    Mulcahy MF, Lewandowski RJ, Ibrahim SM et al. . Radioembolization of colorectal hepatic metastases using yttrium-90 microspheres. Cancer 2009;115:18491858.

    • Search Google Scholar
    • Export Citation
  • 173

    Hong K, McBride JD, Georgiades CS et al. . Salvage therapy for liver-dominant colorectal metastatic adenocarcinoma: comparison between transcatheter arterial chemoembolization versus yttrium-90 radioembolization. J Vasc Interv Radiol 2009;20:360367.

    • Search Google Scholar
    • Export Citation
  • 174

    Katz AW, Carey-Sampson M, Muhs AG et al. . Hypofractionated stereotactic body radiation therapy (SBRT) for patients with limited hepatic metastases. Int J Radiat Oncol Biol Phys 2007;67:793798.

    • Search Google Scholar
    • Export Citation
  • 175

    Yu T-K, Bhosale PR, Crane CH et al. . Patterns of locoregional recurrence after surgery and radiotherapy or chemoradiation for rectal cancer. Int J Rad Oncol Biol Phys 2008;71:11751180.

    • Search Google Scholar
    • Export Citation
  • 176

    Lowy AM, Rich TA, Skibber JM et al. . Preoperative infusional chemoradiation, selective intraoperative radiation, and resection for locally advanced pelvic recurrence of colorectal adenocarcinoma. Ann Surg 1996;223:177185.

    • Search Google Scholar
    • Export Citation
  • 177

    Hoffman JP, Riley L, Carp NZ, Litwin S. Isolated locally recurrent rectal cancer: a review of incidence, presentation, and management. Semin Oncol 1993;20:506519.

    • Search Google Scholar
    • Export Citation
  • 178

    Bartlett DL, Berlin J, Lauwers GY et al. . Chemotherapy and regional therapy of hepatic colorectal metastases: expert consensus statement. Ann Surg Oncol 2006;13:12841292.

    • Search Google Scholar
    • Export Citation
  • 179

    Pelosi E, Deandreis D. The role of 18F-fluoro-deoxy-glucose positron emission tomography (FDG-PET) in the management of patients with colorectal cancer. Eur J Surg Oncol 2007;33:16.

    • Search Google Scholar
    • Export Citation
  • 180

    Dresen RC, Gosens MJ, Martijn H et al. . Radical resection after IORT-containing multimodality treatment is the most important determinant of outcome in patients with locally recurrent rectal cancer. Ann Surg Oncol 2008;15:19371947.

    • Search Google Scholar
    • Export Citation
  • 181

    Yan TD, Black D, Savady R, Sugarbaker PH. Systemic review on the efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal carcinoma. J Clin Oncol 2006;24:40114019.

    • Search Google Scholar
    • Export Citation
  • 182

    Esquivel J, Sticca R, Sugarbaker P et al. . Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Society of Surgical Oncology. Ann Surg Oncol 2007;14:128133.

    • Search Google Scholar
    • Export Citation
  • 199

    Sprangers MAG, Taal BG, Aaronson NK et al. . Quality of life in colorectal cancer: stoma vs. nonstoma patients. Dis Colon Rectum 1995;38:361369.

  • 200

    Lange MM, Mass CP, Marijnen CAM et al. . Urinary dysfunction after rectal cancer treatment is mainly caused by surgery. Br J Cancer 2008;95:10201028.

    • Search Google Scholar
    • Export Citation
  • 201

    Lange MM, Mass CP, Marijnen CAM et al. . Risk factors for sexual dysfunction after rectal cancer treatment. Eur J Cancer 2009;45:15781588.

  • 202

    DeSnoo L, Faithfull S. A qualitative study of anterior resection syndrome: the experiences of cancer survivors who have undergone resection surgery. Eur J Cancer Care 2006;15:244251.

    • Search Google Scholar
    • Export Citation
  • 203

    Baxter NN, Habermann EB, Tepper JE et al. . Risk of pelvic fractures in older women following pelvic irradiation. JAMA 2005;294:25872593.

  • 204

    Denlinger CS, Barsevick AM. The Challenges of Colorectal Cancer Survivorship. J Natl Cancer Netw 2009;7:in press.

  • 205

    Dignam JL, Polite BN, Yothers G et al. . Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer. J Natl Cancer Inst 2006;98:16471654.

    • Search Google Scholar
    • Export Citation
  • 206

    Meyerhardt JA, Heseltine D, Niedzwiecki D et al. . Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol 2006;24:35353541.

    • Search Google Scholar
    • Export Citation
  • 207

    Meyerhardt JA, Niedzwiecki D, Hollis D et al. . Association of dietary patterns with cancer recurrence and survival in patients with stage III colon cancer. JAMA 2007;298:754764.

    • Search Google Scholar
    • Export Citation
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