Testicular Cancer

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Robert J. Motzer
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Neeraj Agarwal
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Clair Beard
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Graeme B. Bolger
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Barry Boston
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Michael A. Carducci
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Toni K. Choueiri
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Robert A. Figlin
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Mayer Fishman
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Steven L. Hancock
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Gary R. Hudes
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Eric Jonasch
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Anne Kessinger
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Timothy M. Kuzel
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Paul H. Lange
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Ellis G. Levine
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Kim A. Margolin
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M. Dror Michaelson
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Thomas Olencki
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Roberto Pili
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Bruce G. Redman
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Cary N. Robertson
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Lawrence H. Schwartz
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Joel Sheinfeld
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Jue Wang
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  • 1

    Jemal A, Siegel R, Ward E et al.. Cancer statistics, 2008. CA Cancer J Clin 2008;58:7196.

  • 2

    Jones RH, Vasey PA. Part I: testicular cancer—management of early disease. Lancet Oncol 2003;4:730737.

  • 3

    Fossa SD, Chen J, Schonfeld SJ et al.. Risk of contralateral testicular cancer: a population based study of 29,515 US men. J Natl Cancer Inst 2005;97:10561066.

  • 4

    Jones WG, Fossa SD, Mead GM et al.. Randomized trial of 30 versus 20 Gy in the adjuvant treatment of stage I testicular seminoma: a report on Medical Research Council Trial TE18, European Organisation for the Research and Treatment of Cancer Trial 30942 (ISRCTN18525328). J Clin Oncol 2005;23:12001208.

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  • 5

    Oliver RT, Mason MD, Mead GM et al.. Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: a randomized trial. Lancet 2005;366:293300.

  • 6

    Oliver RT, Mead GM & Fogarty PJ et al. Radiotherapy versus carboplatin for stage I seminoma: updated analysis of the MRC/EORTC randomized trial (ISRCTN27163214) [abstract]. J Clin Oncol 2008;26:(Suppl 1):Abstract 1.

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  • 7

    Alomary I, Samant R, Gallant V. Treatment of stage I seminoma: a 15 year review. Urol Oncol 2006;24:180183.

  • 8

    Gospodarowicz M, Sturgeon JF, Jewitt MA. Early stage and advanced seminoma: role of radiation therapy, surgery, and chemotherapy. Semin Oncol 1998;25:160173.

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    de Wit R, Roberts JT, Wilkinson PM et al.. Equivalence of three or four cycles of bleomycin, etoposide, and cisplatin chemotherapy and of a 3- or 5-day schedule in good-prognosis germ cell cancer: a randomized study of the European Organization for Research and Treatment of Cancer Genitourinary Tract Cancer Cooperative Group and the Medical Research Council. J Clin Oncol 2001;19:16291640.

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  • 10

    Loehrer PJ Sr, Johnson D, Elson P et al.. Importance of bleomycin in favorable-prognosis disseminated germ cell tumors: an Eastern Cooperative Oncology Group trial. J Clin Oncol 1995;13:470476.

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  • 11

    Bajorin DF, Sarosdy MF, Pfister DG et al.. Randomized trial of etoposide and cisplatin versus etoposide and carboplatin in patients with good-risk germ cell tumors: a multiinstitutional study. J Clin Oncol 1993;11:598606.

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  • 12

    Kondagunta GV, Bacik J, Bajorin D et al.. Etoposide and cisplatin chemotherapy for metastatic good-risk germ cell tumors. J Clin Oncol 2005;23:92909294.

  • 13

    Becherer A, De Santis M, Karanikas G et al.. FDG PET is superior to CT in the prediction of viable tumour in post-chemotherapy seminoma residuals. Eur J Radiol 2005;54:284288.

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  • 14

    Warde P, Gospodarowicz MK, Panzarella T et al.. Stage I testicular seminoma: results of adjuvant irradiation and surveillance. J Clin Oncol 1995;13:22552262.

  • 15

    Puc HS, Heelan R, Mazumdar M et al.. Management of residual mass in advanced seminoma: results and recommendations from the Memorial Sloan-Kettering Cancer Center. J Clin Oncol 1998;14:454460.

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  • 16

    Mencel PJ, Motzer RJ, Mazumdar M et al.. Advanced seminoma: treatment results, survival, and prognostic factors in 142 patients. J Clin Oncol 1994;12:120126.

  • 17

    Sheinfeld J, Herr H. Role of surgery in management of germ-cell tumors. Semin Oncol 1998;25:203209.

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    Carver BS, Sheinfeld J. The current status of laparoscopic retroperitoneal lymph node dissection for non-seminomatous germ-cell tumors. Nat Clin Pract Urol 2005;2:330335.

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  • 19

    Davis BE, Herr HW, Fair WR et al.. The management of patients with nonseminomatous germ-cell tumors of the testis with serologic disease only after orchiectomy. J Urol 1994;152:111114.

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  • 20

    Culine S, Theodore C, Terrier-Lacombe MJ, Droz JP. Primary chemotherapy in patients with nonseminomatous germ cell tumors of the testis and biological disease only after orchiectomy. J Urol 1996;155:12961298.

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  • 21

    Foster R, Bihrle R. Current status of retroperitoneal lymph node dissection and testicular cancer: when to operate. Cancer Control 2002;9:277283.

  • 22

    Motzer RJ, Sheinfeld J, Mazumdar M et al.. Etoposide and cisplatin adjuvant therapy for patients with pathologic stage II germ-cell tumors. Classic Papers and Current Comments: Highlights of Genitourinary Cancer Research 1998b;2:455459.

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  • 23

    International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group. J Clin Oncol 1997;15:594603.

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  • 24

    Williams SD, Birch R, Einhorn LH et al.. Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med 1987;316:14351440.

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  • 25

    Bosl GJ, Geller NL, Bajorin D et al.. A randomized trial of etoposide + cisplatin vs vinblastine + bleomycin + cisplatin + cyclophosphamide + dactinomycin in patients with good-prognosis germ-cell tumors. J Clin Oncol 1988;6:12311238.

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  • 26

    Einhorn LH, Williams SD, Loehrer PJ et al.. Evaluation of optimal duration of chemotherapy in favorable-prognosis disseminated germ-cell tumors: a Southeastern Cancer Study Group protocol. J Clin Oncol 1989;7:387391.

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  • 27

    Jones RH, Vasey PA. Part II: testicular cancer—management of advanced disease. Lancet Oncol 2003;4:738747.

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    Toner GC, Motzer RJ. Poor prognosis germ-cell tumors: current status and future directions. Semin Oncol 1998;25:194202.

  • 29

    Loehrer PJ Sr, Lauer R, Roth BJ et al.. Salvage therapy in recurrent germ cell cancer: ifosfamide and cisplatin plus either vinblastine or etoposide. Ann Intern Med 1988;109:540546.

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  • 30

    Motzer RJ, Geller NL, Tan CC et al.. Salvage chemotherapy for patients with germ-cell tumors. The Memorial Sloan-Kettering Cancer Center experience (1979–1989). Cancer 1991;67:13051310.

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  • 31

    McCaffrey JA, Mazumdar M, Bajorin DF et al.. Ifosfamide + cisplatin regimens as first-line salvage therapy in germ-cell tumors: response and survival (abstract). Proc Am Soc Clin Oncol 1996;14:Abstract 250.

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  • 32

    Loehrer PJ, Gonin R, Nichols CR et al.. Vinblastine plus ifosfamide plus cisplatin as initial salvage therapy in recurrent germ-cell tumor. J Clin Oncol 1998;16:25002504.

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  • 33

    Motzer RJ, Bosl GJ. High-dose chemotherapy for resistant germ-cell tumors: recent advances and future directions. J Natl Cancer Inst 1992;84:17031709.

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    Beyer J, Kramer A, Mandanas R et al.. High-dose chemotherapy as salvage treatment in germ cell tumors: a multivariate analysis of prognostic variables. J Clin Oncol 1996;14:26382645.

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  • 35

    Wood DP, Herr H, Motzer RJ et al.. Surgical resection of solitary metastases after chemotherapy in patients with non-seminomatous germ-cell tumors and elevated serum tumor markers. Cancer 1992;70:23542357.

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  • 36

    Pectasides D, Pectasides M, Farmakis D et al.. Gemcitabine and oxaliplatin (GEMOX) in patients with cisplatin-refractory germ cell tumors: a phase II study. Ann Oncol 2004;15:493497.

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  • 37

    Kollmannsberger C, Beyer J, Liersch R et al.. Combination chemotherapy with gemcitabine plus oxaliplatin in patients with intensively pretreated or refractory germ cell cancer: a study of the German Testicular Cancer Study Group. J Clin Oncol 2004;22:108114.

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  • 38

    De Giorgi U, Rosti G, Aieta M et al.. Phase II study of oxaliplatin and gemcitabine salvage chemotherapy in patients with cisplatin-refractory nonseminomatous germ cell tumor. Eur Urol 2006;50:10321038; discussion 1038–1039.

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