Antiemesis

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Debra K. Armstrong
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Dean Lim
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Carli Nesheiwat
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Hope S. Rugo
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  • 1

    Laszlo J. Emesis as limiting toxicity in cancer chemotherapy. In: Laszlo J, ed. Antiemetics and Cancer Chemotherapy. Baltimore: Williams & Wilkins; 1983:15.

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  • 9

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  • 11

    Hickok JT, Roscoe JA, Morrow GR et al.. 5-Hydroxytryptamine-receptor antagonists versus prochlorperazine for control of delayed nausea caused by doxorubicin: a URCC CCOP randomised controlled trial. Lancet Oncol 2005;6:765772.

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  • 12

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  • 17

    Roila F, Boschetti E, Tonato M et al.. Predictive factors of delayed emesis in cisplatin patients and anti-emetic activity and tolerability of metoclopramide or dexamethasone. Am J Clin Oncol 1991;14:238242.

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  • 18

    Moher D, Arthur AZ, Peter JL. Anticipatory nausea and/or vomiting in chemotherapy patients. Cancer Treat Rev 1984;11:257264.

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    Jacobsen PB, Redd WH. The development and management of chemotherapy-related anticipatory nausea and vomiting. Cancer Invest 1988;6:329336.

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    Morrow GR. Clinical characteristics associated with the development of anticipatory nausea and vomiting in cancer patients undergoing chemotherapy treatment. J Clin Oncol 1984;2:11701176.

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  • 21

    Harding RK, Young RW, Anno GH. Radiotherapy-induced emesis. In: Andrews PLR, Sanger GJ, eds. Emesis in Anti-Cancer Therapy. London: Chapman & Hall Medical; 1993:163178.

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  • 22

    Roila F, Hesketh PJ, Herrstedt J et al.. Prevention of chemotherapy- and radiotherapy-induced emesis: results of the 2004 Perugia International Antiemetic Consensus Conference. Ann Oncol 2006;17:2028.

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  • 23

    Kris MG, Hesketh PJ, Somerfield MR et al.. American Society of Clinical Oncology guideline for antiemetics in oncology: update 2006. J Clin Oncol 2006;24:29322947.

  • 24

    Laszlo J. Treatment of nausea and vomiting caused by cancer chemotherapy. Cancer Treat Rev 1982;9:39.

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    Strum SB, McDermed JE, Pileggi J et al.. Intravenous metoclopramide: prevention of chemotherapy-induced nausea and vomiting. Cancer 1984;53:14321439.

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    Lindley CM, Bernard S, Fields SM. Incidence and duration of chemotherapy-induced nausea and vomiting in the outpatient oncology population. J Clin Oncol 1989;7:11421149.

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  • 27

    Aapro MS. Methodological issues in anti-emetic studies. Invest New Drugs 1993;11:243253.

  • 28

    Hesketh PJ, Kris MG, Grunberg SM et al.. Proposal for classifying the acute emetogenicity of cancer chemotherapy. J Clin Oncol 1997;15:103109.

  • 29

    Grunberg SM, Osoba D, Hesketh PJ et al.. Evaluation of new antiemetic agents and definition of antineoplastic agent emetogenicity–an update. Support Care Cancer 2005;13:8084.

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  • 30

    Koeller JM, Aapro MS, Gralla RJ et al.. Antiemetic guidelines: creating a more practical treatment approach. Support Care Cancer 2002;10:519522.

  • 31

    Hesketh PJ, Gandara DR. Serotonin antagonists: a new class of antiemetic agents. J Natl Cancer Inst 1991;83:613620.

  • 32

    Andrews PL, Bhandari P, Davey PT et al.. Are all 5-HT3 receptor antagonists the same? Eur J Cancer 1992;28A(Suppl 1):S26.

  • 33

    Grunberg SM, Koeller JM. Palonosetron: a unique 5-HT3-receptor antagonist for the prevention of chemotherapy-induced emesis. Expert Opin Pharmacother 2003;4:22972303.

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  • 34

    Grunberg SM, Stevenson LL, Russell CA et al.. Dose-ranging phase I study of the serotonin antagonist GR 38032F for prevention of cisplatin-induced nausea and vomiting. J Clin Oncol 1989;7:11371141.

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  • 35

    Chevallier B. Efficacy and safety of granisetron compared with high-dose metoclopramide plus dexamethasone in patients receiving high-dose cisplatin in a single-blind study. Eur J Cancer 1990;26:S3336.

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  • 36

    Cupissol DR, Serrou B, Caubel M. The efficacy of granisetron as prophylactic anti-emetic and intervention agent in high-dose cisplatin-induced emesis. Eur J Cancer 1990;26:S2327.

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  • 37

    DeMulder PHM, Seynaeve C, Vermorken JB et al.. Ondansetron compared with high-dose metoclopramide in prophylaxis of acute and delayed cisplatin-induced nausea and vomiting. Ann Intern Med 1990;113:834840.

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  • 38

    Marty M. A comparative study of the use of granisetron, a selective 5-HT3 antagonist, versus a standard anti-emetic regimen of chlorpromazine plus dexamethasone in the treatment of cytostatic-induced emesis. Eur J Cancer 1990;26(Suppl 1):S2832.

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  • 39

    Marty M, Pouillart P, School S et al.. Comparison of the 5-hydroxytryptamine3 (serotonin) receptor antagonist ondansetron (GR 38032F) with high-dose metoclopramide in the control of cisplatin-induced emesis. N Engl J Med 1990;322:816821.

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  • 40

    Soukop M. A comparison of two dose levels of granisetron in patients receiving high-dose cisplatin. Eur J Cancer 1990;26(Suppl 1):S1519.

  • 41

    Roila F, Tonato M, Cognetti F et al.. Prevention of cisplatin-induced emesis: a double-blind multicenter randomized crossover study comparing ondansetron and ondansetron plus dexamethasone. J Clin Oncol 1991;9:675678.

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  • 42

    Fraschini G. Antiemetic activity of ondansetron in cancer patients receiving non-cisplatin chemotherapy. Semin Oncol 1992;19(4 Suppl 10):S4147.

  • 43

    Kamanabrou D. Intravenous granisetron establishing the optimal dose. Eur J Cancer 1992;28A(Suppl 1):S611.

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    Sledge GW Jr, Einhorn L, Nagy C et al.. Phase III double-blind comparison of intravenous ondansetron and metoclopramide as antiemetic therapy for patients receiving multiple-day cisplatin-based chemotherapy. Cancer 1992;70:25242528.

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  • 45

    Chevallier B. The control of acute cisplatin-induced emesis—a comparative study of granisetron and combination regimen of high-dose metoclopramide and dexamethasone. Br J Cancer 1993;68:176180.

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  • 46

    Navari RM, Kaplan HG, Gralla RJ et al.. Efficacy and safety of granisetron, a selective 5-HT antagonist, in the prevention of nausea and vomiting induced by high dose cisplatin. J Clin Oncol 1994;12:22042210.

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  • 47

    Riviere A. Dose-finding study of granisetron in patients receiving high-dose cisplatin chemotherapy. Br J Cancer 1994;69:967971.

  • 48

    Eisenberg P, Figueroa-Vadillo J, Zamora R et al.. Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist: results of a phase III, single-dose trial versus dolasetron. Cancer 2003;98:24732482.

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  • 49

    Aapro MS. Palonosetron as an anti-emetic and anti-nausea agent in oncology. Ther Clin Risk Manag 2007;3:10091020.

  • 50

    Grunberg S, Gabrial N, Clark G. Phase III trial of transdermal granisetron patch (Sancuso) compared to oral granisetron (OG) for chemotherapy-induced nausea and vomiting (CINV) after multi-day moderately emetogenic (MEC) or highly emetogenic (HEC) chemotherapy [Abstract]. MASCC/ISOO 20th Anniversary International Symposium Supportive Care in Cancer; St. Gallen, Switzerland; June 27–30, 2007:687. Astract P-18.

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  • 51

    Gralla R, Lichinitser M, Van Der Vegt S et al.. Palonosetron improves prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy: results of a double-blind randomized phase III trial comparing single doses of palonosetron with ondansetron. Ann Oncol 2003;14:15701577.

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  • 52

    Bonneterre J, Hecquet B. Granisetron (IV) compared with ondansetron (IV plus oral) in the prevention of nausea and vomiting induced by moderately emetogenic chemotherapy. A crossover study. Bull Cancer 1995;82:10381043.

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  • 53

    Jantunen IT, Kataja VV, Johansson RT. Ondansetron and tropisetron with dexamethasone in the prophylaxis of acute nausea and vomiting induced by non-cisplatin-containing chemotherapy. Acta Oncol 1992;31:573575.

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  • 54

    Jantunen IT, Muhonen TT, Kataja VV et al.. 5-HT3 receptor antagonists in the prophylaxis of acute vomiting induced by moderately emetogenic chemotherapy—a randomised study. Eur J Cancer 1993;29A:16691672.

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  • 55

    Martoni S, Angelelli B, Guaraldi M et al.. Granisetron (GRA) vs. ondansetron (OND) in the prevention of cisplatinum-induced emesis: an open randomized cross-over study. Am Soc Lin Oncol 1993;13:431.

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  • 56

    Campora LE, Simoni C, Rosso R. [Tropisetron versus ondansetron in the prevention and control of emesis in patients undergoing chemotherapy with FAC/FEC for metastatic or surgically treated breast carcinoma]. Minerva Med 1994;85:2531 [in Italian].

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  • 57

    Gebbia V, Cannata G, Testa A et al.. Ondansetron versus granisetron in the prevention of chemotherapy-induced nausea and vomiting. Cancer 1994;74:19451952.

  • 58

    Mantovani A, Maccio L, Curreli L et al.. Comparison of the effectiveness of three 5-HT3 receptor antagonists in the prophylaxis of acute vomiting induced by highly emetogenic chemotherapy (high-dose cisplatin) for the treatment of primary head and neck cancer. Proc Am Soc Clin Oncol 1994;13:428.

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  • 59

    Massidda B, Laconi S, Foddi MR et al.. Prevention of non-cisplatin induced emesis: role of the antagonists of 5-HT receptors. Ann Oncol 1994;5:S204.

  • 60

    Noble A, Bremer K, Goedhals L et al.. A double-blind, randomised, crossover comparison of granisetron and ondansetron in 5-day fractionated chemotherapy: assessment of efficacy, safety and patient preference. Eur J Cancer 1994;30:10831088.

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  • 61

    Ruff P, Paska W, Goedhals L et al.. Ondansetron compared with granisetron in the prophylaxis of cisplatin-induced acute emesis: a multicentre double-blind, randomised, parallel-group study. Oncology 1994;51:113118.

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  • 62

    Italian Group for Antiemetic Research. Ondansetron versus granisetron, both combined with dexamethasone, in the prevention of cisplatin-induced emesis. Ann Oncol 1995;6:805810.

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  • 63

    Marty M, Kleisbauer JP, Fournel P et al.. Is navoban (tropisetron) as effective as zofran (ondansetron) in cisplatin-induced emesis? Anti-Cancer Drugs 1995;6(Suppl 1):S1521.

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  • 64

    Navari R, Gandara D, Hesketh P et al.. Comparative clinical trial of granisetron and ondansetron in the prophylaxis of cisplatin-induced emesis. J Clin Oncol 1995;13:12421248.

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  • 65

    Stewart A, McQuade B, Cronje JDE et al.. Ondansetron compared with granisetron in the prophylaxis of cyclophosphamide-induced emesis in outpatients: a multi-centre, double-blind, double dummy, randomised, parallel-group study. Oncology 1995;52:202210.

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  • 66

    Audhuy B, Cappelaere P, Martin M et al.. A double-blind, randomised comparison of the antiemetic efficacy of two intravenous doses of dolasetron mesilate and granisetron in patients receiving high dose cisplatin chemotherapy. Eur J Cancer 1996;32A:807813.

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  • 67

    Fauser AA, Duclos B, Chemaissani A et al.. Therapeutic equivalence of single oral doses of dolasetron mesilate and multiple doses of ondaneston for the prevention of amesis after moderately emetogenic chemotherapy. European Dolasetron Comparative Study Group. Eur J Cancer 1996;32A:15231529.

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  • 68

    Hesketh PJ, Navari R, Grote T et al.. Double-blind, randomised comparison of the antiemetic efficacy of intravenous dolasetron mesylate and intravenous ondansetron in the prevention of acute cisplatin-induced emesis in patients with cancer. J Clin Oncol 1996;14:22422249.

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  • 69

    Leonardi V, Iannitto E, Meli M, Palmeri S. Ondansetron vs granisetron in the control of chemotherapy-induced acute emesis: a multicenter randomized trial. Oncology Rep 1996;3:919923.

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  • 70

    Lofters WS, Pater JL, Zee B et al.. Phase III double-blind comparison of dolasetron mesylate and ondansetron, and evaluation of the additive role of dexamethasone in the prevention of acute and delayed nausea and vomiting due to moderately emetogenic chemotherapy. J Clin Oncol 1997;15:29662973.

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  • 71

    Jordan K, Hinke A, Grothey A et al.. A meta-analysis comparing the efficacy of four 5-HT3-receptor antagonists for acute chemotherapy-induced emesis. Support Care Cancer 2007;15:10231033.

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  • 72

    Huang JQ, Zheng GF, Deuson R et al.. Do 5-hydroxytryptamine3 receptor antagonists (5-HT3) improve the antiemetic effect of dexamethasone for preventing delayed chemotherapy-induced nausea and vomiting (CINV)? A meta-analysis of randomized controlled trials [Abstract]. J Clin Oncol 2004;22:Abstract 6037.

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  • 73

    Chawla SP, Grunberg SM, Gralla RJ et al.. Establishing the dose of the oral NK1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting. Cancer 2003;97:22902300.

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  • 74

    Hesketh PJ, Grunberg SM, Gralla RJ et al.. The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a multinational, randomized, double-blind, placebo-controlled trial in patients receiving high-dose cisplatin—the Aprepitant Protocol 052 Study Group. J Clin Oncol 2003;21:41124119.

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  • 75

    de Wit R, Herrstedt J, Rapoport B et al.. The oral NK(1) antagonist, aprepitant, given with standard antiemetics provides protection against nausea and vomiting over multiple cycles of cisplatin-based chemotherapy: a combined analysis of two randomised, placebo-controlled phase III clinical trials. Eur J Cancer 2004;40:403410.

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  • 76

    Warr DG, Eisenberg P, Hesketh PJ et al.. Effect of aprepitant for the prevention of nausea and vomiting after one cycle of moderately emetogenic chemotherapy: a randomized double-blind trial in 866 patients [Abstract]. J Clin Oncol 2004;22:Abstract 8007.

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  • 77

    Warr DG, Hesketh PJ, Gralla RJ et al.. Efficacy and tolerability of aprepitant for the prevention of chemotherapy-induced nausea and vomiting in patients with breast cancer after moderately emetogenic chemotherapy. J Clin Oncol 2005;23:28222830.

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  • 78

    Gralla RJ, Warr DG, Carides AD et al.. Effect of aprepitant on antiemetic protection in patients receiving moderately emetogenic chemotherapy plus high-dose cisplatin: analysis of combined data from 2 phase III randomized clinical trials [abstract]. J Clin Oncol 2004;22:Abstract 8137.

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  • 79

    Tremont-Lukats IW, González-Barboteo J, Bruera E et al.. Meta-analysis of neurokinin-1 receptor antagonists (NK-1 RA) for chemotherapy-induced nausea and vomiting (CINV) [Abstract]. J Clin Oncol 2004;22:Abstract 8047.

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  • 80

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    Navari RM, Einhorn LH, Loehrer PJ et al.. A phase II trial of olanzapine for the prevention of chemotherapy induced nausea and vomiting (CINV) [Abstract]. J Clin Oncol 2004;22:Abstract 8046.

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    Navari RM, Einhorn LH, Passik SD et al.. A phase II trial of olanzapine for the prevention of chemotherapy-induced nausea and vomiting: a Hoosier Oncology Group study. Support Care Cancer 2005;13:529534.

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    Srivastava M, Brito-Dellan N, Davis MP et al.. Olanzapine as an antiemetic in refractory nausea and vomiting in advanced cancer. J Pain Symptom Manage 2003;25:578582.

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    Passik SD, Kirsh KL, Theobald DE et al.. A retrospective chart review of the use of olanzapine for the prevention of delayed emesis in cancer patients. J Pain Symptom Manage 2003;25:485488.

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    Passik SD, Lundberg J, Kirsh KL et al.. A pilot exploration of the antiemetic activity of olanzapine for the relief of nausea in patients with advanced cancer and pain. J Pain Symptom Manage 2002;23:526532.

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    Morita T, Tei Y, Shishido H et al.. Olanzapine-induced delirium in a terminally ill cancer patient. J Pain Symptom Manage 2004;28:102103.

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    Saito M, Aogi K, Sekine I et al.. Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randomised, comparative phase III trial. Lancet Oncol 2009;10:115124.

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