Myeloid Growth Factors

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Jeffrey Crawford
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James Armitage
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Lodovico Balducci
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Charles Bennett
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Douglas W. Blayney
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Spero R. Cataland
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David C. Dale
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George D. Demetri
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James Foran
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Alison G. Freifeld
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Marti Goemann
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Mark L. Heaney
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Sally Htoy
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Susan Hudock
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Dwight D. Kloth
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David J. Kuter
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Gary H. Lyman
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Laura Boehnke Michaud
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Sarah C. Miyata
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Martin S. Tallman
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Saroj Vadhan-Raj
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Peter Westervelt
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Michael K. Wong
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  • 1

    Dale DC, McCarter GC, Crawford J. Myelotoxicity and dose intensity of chemotherapy: reporting practices from randomized clinical trials. J Natl Compr Canc Netw 2003;1:440454.

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  • 2

    Dale DC. Colony-stimulating factors for the management of neutropenia in cancer patients. Drugs 2002;62(Suppl 1):115.

  • 3

    Lyman GH, Kuderer NM. Filgrastim in patients with neutropenia: potential effects on quality of life. Drugs 2002;62(Suppl 1):6578.

  • 4

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  • 5

    Timmer-Bonte JN, de Boo TM, Smit HJ et al.. Prevention of chemotherapy-induced febrile neutropenia by prophylactic antibiotics plus or minus granulocyte colony-stimulating factor in small-cell lung cancer: a Dutch randomized phase III study. J Clin Oncol 2005;23:79747984.

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  • 6

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  • 7

    Vogel CL, Wojtukiewicz MZ, Carroll RR et al.. First and subsequent cycle use of pegfilgrastim prevents febrile neutropenia in patients with breast cancer: a multicenter, double-blind, placebo-controlled phase III study. J Clin Oncol 2005;23:11781184.

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  • 8

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  • 9

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  • 10

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  • 11

    Gatzemeier U, Kleisbauer JP, Drings P et al.. Lenograstim as support for ACE chemotherapy of small-cell lung cancer: a phase III, multicenter, randomized study. Am J Clin Oncol 2000;23:393400.

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  • 12

    Muhonen T, Jantunen I, Pertovaara H et al.. Prophylactic filgrastim (G-CSF) during mitomycin-C, mitoxantrone, and methotrexate (MMM) treatment for metastatic breast cancer. A randomized study. Am J Clin Oncol 1996;19:232234.

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  • 13

    Osby E, Hagberg H, Kvaloy S et al.. CHOP is superior to CNOP in elderly patients with aggressive lymphoma while outcome is unaffected by filgrastim treatment: results of a Nordic Lymphoma Group randomized trial. Blood 2003;101:38403848.

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  • 14

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  • 15

    Zinzani PL, Pavone E, Storti S et al.. Randomized trial with or without granulocyte colony-stimulating factor as adjunct to induction VNCOP-B treatment of elderly high-grade non-Hodgkin’s lymphoma. Blood 1997;89:39743979.

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  • 16

    Doorduijn JK, van der Holt B, van Imhoff GW et al.. CHOP compared with CHOP plus granulocyte colony-stimulating factor in elderly patients with aggressive non-Hodgkin’s lymphoma. J Clin Oncol 2003;21:30413050.

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  • 17

    Fossa SD, Kaye SB, Mead GM et al.. Filgrastim during combination chemotherapy of patients with poor-prognosis metastatic germ cell malignancy. European Organization for Research and Treatment of Cancer, Genito-Urinary Group, and the Medical Research Council Testicular Cancer Working Party, Cambridge, United Kingdom. J Clin Oncol 1998;16:716724.

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  • 18

    Citron ML, Berry DA, Cirrincione C et al.. Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741. J Clin Oncol 2003;21:14311439.

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  • 19

    Pfreundschuh M, Trumper L, Kloess M et al.. Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: results of the NHL-B2 trial of the DSHNHL. Blood 2004;104:634641.

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  • 20

    Bohlius J, Reiser M, Schwarzer G, Engert A. Granulopoiesis-stimulating factors to prevent adverse effects in the treatment of malignant lymphoma. Cochrane Database Syst Rev 2004:CD003189.

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  • 21

    Sung L, Nathan PC, Alibhai SM et al.. Meta-analysis: effect of prophylactic hematopoietic colony-stimulating factors on mortality and outcomes of infection. Ann Intern Med 2007;147:400411.

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  • 22

    Clark OA, Lyman GH, Castro AA et al.. Colony-stimulating factors for chemotherapy-induced febrile neutropenia: a meta-analysis of randomized controlled trials. J Clin Oncol 2005;23:41984214.

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  • 23

    Kuderer NM, Dale DC, Crawford J, Lyman GH. Impact of primary prophylaxis with granulocyte colony-stimulating factor on febrile neutropenia and mortality in adult cancer patients receiving chemotherapy: a systematic review. J Clin Oncol 2007;25:31583167.

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  • 24

    Lyman GH, Kuderer NM. The economics of the colony-stimulating factors in the prevention and treatment of febrile neutropenia. Crit Rev Oncol Hematol 2004;50:129146.

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  • 25

    Cosler LE, Eldar-Lissai A, Culakova E et al.. Therapeutic use of granulocyte colony-stimulating factors for established febrile neutropenia: effect on costs from a hospital perspective. Pharmacoeconomics 2007;25:343351.

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  • 26

    Doorduijn JK, Buijt I, van der Holt B et al.. Economic evaluation of prophylactic granulocyte colony stimulating factor during chemotherapy in elderly patients with aggressive non-Hodgkin’s lymphoma. Haematologica 2004;89:11091117.

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  • 27

    Eldar-Lissai A, Cosler LE, Culakova E, Lyman GH. Economic analysis of prophylactic pegfilgrastim in adult cancer patients receiving chemotherapy. Value Health 2008;11:172179.

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  • 28

    Numnum TM, Kimball KJ, Rocconi RP et al.. Pegfilgrastim for the prevention of febrile neutropenia in patients with epithelial ovarian carcinoma—a cost-effectiveness analysis. Int J Gynecol Cancer 2007;17:10191024.

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  • 29

    Timmer-Bonte JN, Adang EM, Termeer E et al.. Modeling the cost effectiveness of secondary febrile neutropenia prophylaxis during standard-dose chemotherapy. J Clin Oncol 2008;26:290296.

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  • 31

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  • 32

    Tigue CC, McKoy JM, Evens AM et al.. Granulocyte-colony stimulating factor administration to healthy individuals and persons with chronic neutropenia or cancer: an overview of safety considerations from the Research on Adverse Drug Events and Reports project. Bone Marrow Transplant 2007;40:185192.

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  • 33

    Aapro MS, Cameron DA, Pettengell R et al.. EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphomas and solid tumours. Eur J Cancer 2006;42:24332453.

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  • 34

    Smith TJ, Khatcheressian J, Lyman GH et al.. 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline. J Clin Oncol 2006;24:31873205.

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  • 35

    Crawford J, Dale DC, Lyman GH. Chemotherapy-induced neutropenia: risks, consequences, and new directions for its management. Cancer 2004;100:228237.

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    Azoulay E, Attalah H, Harf A et al.. Granulocyte colony-stimulating factor or neutrophil-induced pulmonary toxicity: myth or reality? Systematic review of clinical case reports and experimental data. Chest 2001;120:16951701.

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    Evens AM, Cilley J, Ortiz T et al.. G-CSF is not necessary to maintain over 99% dose-intensity with ABVD in the treatment of Hodgkin lymphoma: low toxicity and excellent outcomes in a 10-year analysis. Br J Haematol 2007;137:545552.

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    Lyman GH, Lyman CH, Agboola O. Risk models for predicting chemotherapy-induced neutropenia. Oncologist 2005;10:427437.

  • 40

    Aslani A, Smith RC, Allen BJ et al.. The predictive value of body protein for chemotherapy-induced toxicity. Cancer 2000;88:796803.

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    Chrischilles E, Delgado DJ, Stolshek BS et al.. Impact of age and colony-stimulating factor use on hospital length of stay for febrile neutropenia in CHOP-treated non-Hodgkin’s lymphoma. Cancer Control 2002;9:203211.

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    Lyman GH, Delgado DJ. Risk and timing of hospitalization for febrile neutropenia in patients receiving CHOP, CHOP-R, or CNOP chemotherapy for intermediate-grade non-Hodgkin lymphoma. Cancer 2003;98:24022409.

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    Lyman GH, Morrison VA, Dale DC et al.. Risk of febrile neutropenia among patients with intermediate-grade non-Hodgkin’s lymphoma receiving CHOP chemotherapy. Leuk Lymphoma 2003;44:20692076.

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    Lyman GH, Dale DC, Crawford J. Incidence and predictors of low dose-intensity in adjuvant breast cancer chemotherapy: a nationwide study of community practices. J Clin Oncol 2003;21: 45244531.

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    Lyman GH, Dale DC, Friedberg J et al.. Incidence and predictors of low chemotherapy dose-intensity in aggressive non-Hodgkin’s lymphoma: a nationwide study. J Clin Oncol 2004;22:43024311.

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  • 47

    Berghmans T, Paesmans M, Lafitte JJ et al.. Therapeutic use of granulocyte and granulocyte-macrophage colony-stimulating factors in febrile neutropenic cancer patients. A systematic review of the literature with meta-analysis. Support Care Cancer 2002;10:181188.

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    Crawford J. Once-per-cycle pegfilgrastim (Neulasta) for the management of chemotherapy-induced neutropenia. Semin Oncol 2003;30:2430.

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  • 51

    Lokich JJ. Same day pegfilgrastim and CHOP chemotherapy for non-Hodgkin lymphoma. Am J Clin Oncol 2006;29:361363.

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    Kaufman PA, Paroly W, Rinaldi D. Randomized double blind phase 2 study evaluating same-day vs. next-day administration of pegfilgrastim with docetaxel, doxorubicin and cyclophosphamide (TAC) in women with early stage and advanced breast cancer SABCS [abstract]. Breast Cancer Res Treat 2004;88:Abstract 1054.

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  • 53

    Belani CP, Ramalingam S, Al-Janadi A et al.. A randomized double-blind phase II study to evaluate same-day vs next-day administration of pegfilgrastim with carboplatin and docetaxel in patients with NSCLC [abstract]. J Clin Oncol 2006;24(Suppl 1):Abstract 7110.

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  • 54

    Stull DM, Bilmes R, Kim H, Fichtl R. Comparison of sargramostim and filgrastim in the treatment of chemotherapy-induced neutropenia. Am J Health Syst Pharm 2005;62:8387.

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  • 55

    Dale DC, Bonilla MA, Davis MW et al.. A randomized controlled phase III trial of recombinant human granulocyte colony-stimulating factor (filgrastim) for treatment of severe chronic neutropenia. Blood 1993;81:24962502.

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