Neoadjuvant Chemotherapy in Stage III NSCLC

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  • 1 From the University of Tennessee Cancer Institute, Memphis, Tennessee.
  • 2 Medical/Scientific Editor, Journal of the National Comprehensive Cancer Network
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  • 1 From the University of Tennessee Cancer Institute, Memphis, Tennessee.
  • 2 Medical/Scientific Editor, Journal of the National Comprehensive Cancer Network

Non-small cell lung cancer (NSCLC) continues to be the leading cause of cancer-related mortality in the United States. Current standard care for treating NSCLC is surgical resection, when feasible, followed by adjuvant chemotherapy in stages II and III. Neoadjuvant or induction chemotherapy may have several potential advantages compared with adjuvant chemotherapy and has been evaluated in randomized and nonrandomized clinical trials in NSCLC. This article reviews the data for neoadjuvant chemotherapy in NSCLC with a particular focus on regionally advanced disease (stage III) that is still amenable to surgical resection.

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Correspondence: Mohammad Jahanzeb, MD, University of Tennessee Cancer Institute, 1331 Union Avenue, Memphis, TN 38104. E-mail: mj@tennessee.edu

Disclosure: Kerrin G. Robinson, MA, has disclosed no relevant financial relationships.

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