Adjuvant Chemotherapy for Lung Cancer: Cisplatin Doublets Only?

Authors:
Daniel Morgensztern From the Division of Oncology, Department of Medicine, Washington University School of Medicine, and Division of Hematology and Oncology, St. Louis Veterans Affairs Medical Center, St. Louis, Missouri.
From the Division of Oncology, Department of Medicine, Washington University School of Medicine, and Division of Hematology and Oncology, St. Louis Veterans Affairs Medical Center, St. Louis, Missouri.

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Ramaswamy Govindan From the Division of Oncology, Department of Medicine, Washington University School of Medicine, and Division of Hematology and Oncology, St. Louis Veterans Affairs Medical Center, St. Louis, Missouri.

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Volume/Issue:
Volume 6: Issue 3
Online Publication Date:
Mar 2008
DOI:
https://doi.org/10.6004/jnccn.2008.0023
Full access

Lung cancer is the leading cause of cancer-related mortality world-wide. Despite adequate resection, more than half of patients die of recurrent disease, usually at distant sites. Adjuvant systemic chemotherapy is mainly used to eradicate micrometastatic disease. Since the seminal 1995 meta-analysis from earlier studies showed a trend toward improved survival with the use of cisplatin-based adjuvant chemotherapy, several randomized prospective adjuvant trials have addressed this question and eventually established the role for platinum-based adjuvant chemotherapy in patients with stage II or IIIA non–small cell lung cancer who have undergone complete resection. The role of adjuvant chemotherapy in patients with stage I disease remains controversial. Although no clinical or molecular predictors of recurrent disease after surgical resection are reliable, encouraging preliminary data on gene expression studies suggest that identifying, and perhaps treating, only patients at high risk for relapse might be possible in the near future. Furthermore, molecular predictors of resistance may guide the selection of chemotherapy in this setting.

Correspondence: Ramaswamy Govindan, MD, Division of Oncology, Suite 108, 4960 Childrens' Place, St. Louis, MO 63110. E-mail: rgovinda@im.wustl.edu
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Print ISSN:
1540-1405
Online ISSN:
1540-1413
Publisher:
National Comprehensive Cancer Network
Cover Journal of the National Comprehensive Cancer Network
  • 1.

    Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol 2001;2:533–543.

  • 2.

    Jemal A, Siegel R, Ward E et al.. Cancer statistics, 2007. CA Cancer J Clin 2007;57:43–66.

  • 3.

    Govindan R, Page N, Morgensztern D et al.. Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol 2006;24:4539–4544.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Mountain CF. Revisions in the International System for Staging Lung Cancer. Chest 1997;111:1710–1717.

  • 5.

    Harpole DH Jr, Herndon JE II, Young WG Jr et al.. Stage I nonsmall cell lung cancer. A multivariate analysis of treatment methods and patterns of recurrence. Cancer 1995;76:787–796.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Martini N, Bains MS, Burt ME et al.. Incidence of local recurrence and second primary tumors in resected stage I lung cancer. J Thorac Cardiovasc Surg 1995;109:120–129.

  • 7.

    Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. Non-small Cell Lung Cancer Collaborative Group. BMJ 1995;311:899–909.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Scagliotti GV, Fossati R, Torri V et al.. Randomized study of adjuvant chemotherapy for completely resected stage I, II, or IIIA non-small-cell Lung cancer. J Natl Cancer Inst 2003;95:1453–1461.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Waller D, Peake MD, Stephens RJ et al.. Chemotherapy for patients with non-small cell lung cancer: the surgical setting of the Big Lung Trial. Eur J Cardiothorac Surg 2004;26:173–182.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Arriagada R, Bergman B, Dunant A et al.. Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med 2004;350:351–360.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Winton T, Livingston R, Johnson D et al.. Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer. N Engl J Med 2005;352:2589–2597.

  • 12.

    Douillard JY, Rosell R, De Lena M et al.. Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB-IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial. Lancet Oncol 2006;7:719–727.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Strauss GM, Herndon J, Maddaus MA et al.. Randomized clinical trial of adjuvant chemotherapy with paclitaxel and carboplatin following resection in stage IB non-small cell lung cancer (NSCLC): report of Cancer and Leukemia Group B (CALGB) protocol 9633 [abstract]. J Clin Oncol 2004;22:Abstract 7019.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Strauss GM, Herndon JE II, Maddaus MA et al.. Adjuvant chemotherapy in stage IB non-small cell lung cancer (NSCLC): update of Cancer and Leukemia Group B (CALGB) protocol 9633 [abstract]. J Clin Oncol 2006;24:365s. Abstract 7007.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Pignon JP, Tribodet H, Scagliotti GV et al.. Lung Adjuvant Cisplatin Evaluation (LACE): a pooled analysis of five randomized clinical trials including 4,584 patients [abstract]. J Clin Oncol 2006;24:366s. Abstract 7008

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Hamada C, Tanaka F, Ohta M et al.. Meta-analysis of postoperative adjuvant chemotherapy with tegafur-uracil in non-small-cell lung cancer. J Clin Oncol 2005;23:4999–5006.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Ardizzoni A, Boni L, Tiseo M et al.. Cisplatin- versus carboplatin-based chemotherapy in first-line treatment of advanced non-small-cell lung cancer: an individual patient data meta-analysis. J Natl Cancer Inst 2007;99:847–857.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18.

    Hotta K, Matsuo K, Ueoka H et al.. Meta-analysis of randomized clinical trials comparing cisplatin to carboplatin in patients with advanced non-small-cell lung cancer. J Clin Oncol 2004;22:3852–3859.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Postoperative radiotherapy in non-small-cell lung cancer: systematic review and meta-analysis of individual patient data from nine randomised controlled trials. PORT Meta-analysis Trialists Group. Lancet 1998;352:257–263.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20.

    Postoperative radiotherapy for non-small cell lung cancer. Cochrane Database Syst Rev 2005:CD002142.

  • 21.

    Rescigno J. Use of postoperative radiotherapy for node-positive non-small-cell lung cancer. Clin Lung Cancer 2002;4:35–44.

  • 22.

    Keller SM, Adak S, Wagner H et al.. A randomized trial of postoperative adjuvant therapy in patients with completely resected stage II or IIIA non-small-cell lung cancer. Eastern Cooperative Oncology Group. N Engl J Med 2000;343:1217–1222.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23.

    Gazdar AF. DNA repair and survival in lung cancer—the two faces of Janus. N Engl J Med 2007;356:771–773.

  • 24.

    Lord RV, Brabender J, Gandara D et al.. Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer. Clin Cancer Res 2002;8:2286–2291.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 25.

    Isla D, Sarries C, Rosell R et al.. Single nucleotide polymorphisms and outcome in docetaxel-cisplatin-treated advanced non-small-cell lung cancer. Ann Oncol 2004;15:1194–1203.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    Su D, Ma S, Liu P et al.. Genetic polymorphisms and treatment response in advanced non-small cell lung cancer. Lung Cancer 2007;56:281–288.

  • 27.

    Olaussen KA, Dunant A, Fouret P et al.. DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. N Engl J Med 2006;355:983–991.

  • 28.

    Filipits M, Pirker R, Dunant A et al.. Cell cycle regulators and outcome of adjuvant cisplatin-based chemotherapy in completely resected non-small-cell lung cancer: the International Adjuvant Lung Cancer Trial Biologic Program. J Clin Oncol 2007;25:2735–2740.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 29.

    Seve P, Lai R, Ding K et al.. Class III beta-tubulin expression and benefit from adjuvant cisplatin/vinorelbine chemotherapy in operable non-small cell lung cancer: analysis of NCIC JBR.10. Clin Cancer Res 2007;13:994–999.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 30.

    Shepherd FA, Rodrigues Pereira J, Ciuleanu T et al.. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005;353:123–132.

  • 31.

    Sandler A, Gray R, Perry MC et al.. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006;355:2542–2550.

  • 32.

    Thatcher N, Chang A, Parikh P et al.. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005;366:1527–1537.

    • PubMed
    • Search Google Scholar
    • Export Citation
Copyright:
Copyright © 2008 by the National Comprehensive Cancer Network
Page Numbers:
8
Article Category:
Research Article
Received:
08 Nov 2007
Accepted:
21 Dec 2007
Print Publication Date:
01 Mar 2008
Online Publication Date:
Mar 2008
Keywords:
Non-small cell lung cancer; adjuvant chemotherapy; cisplatin

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