Conservative Management of Adolescents With Abnormal Cytology and Histology

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  • 1 From the Division of Adolescent Medicine, University of California San Francisco, San Francisco, California.

Adolescents remain vulnerable to human papilloma virus (HPV) infection because of certain physiologic characteristics inherent in this age group and common sexual behaviors, including lack of condom use. The commonness of HPV in this age group also results in frequent abnormal cytology. Fortunately, most of the infections are transient, with frequent clearance of HPV and the lesion. Current strategies for adolescents with abnormal cytology include conservative management, avoiding invasive procedures. For cytologic atypical squamous cells of undetermined significance or squamous intraepithelial lesions (SIL), management can be obtaining cytology only at 1-year intervals for up to 2 years before referral for colposcopy is necessary. For biopsy-proven cervical intraepithelial neoplasia (CIN) I, management is similar with yearly cytology indefinitely or until high-grade–SIL or CIN II/III develops. CIN II in adherent adolescents can be managed with 6-month cytology and colposcopy.

Correspondence: Anna-Barbara Moscicki, MD, University of California San Francisco, 3333 California Street, Suite 245, San Francisco, CA 94118. E-mail: moscickia@peds.ucsf.edu
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