Targeted Strategies in the Treatment of Metastatic Colon Cancer

Authors:
Diane Reidy From the Division of Solid Tumor Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York.

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 MD, MS
and
Leonard Saltz From the Division of Solid Tumor Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York.

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Volume/Issue:
Volume 5: Issue 9
Online Publication Date:
Oct 2007
DOI:
https://doi.org/10.6004/jnccn.2007.0082
Full access

Advances in the understanding of tumor biology have led to the identification of important cellular processes involved in the pathogenesis of colon cancer. Drugs that interfere with these critical pathways are known as targeted agents. The goal of these therapies is to selectively interrupt the signal transduction pathways responsible for tumor growth and survival. Some of these targeted agents have made important, albeit modest, contributions to the treatment of patients with metastatic colorectal cancer. However, the activity levels with the currently available targeted therapies are far lower than experts had hoped, and toxicities are often nontrivial. This article reviews the available therapies, the data that justify their use, and the challenges of optimizing targeted therapies through combinations with cytotoxic chemotherapies and other targeted agents. Finally, some newer drugs and strategies currently being tested in clinical trials are discussed.

Correspondence: Leonard Saltz, MD, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Room H-917, New York, NY 10021. E-mail: saltzl@mskcc.org
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Print ISSN:
1540-1405
Online ISSN:
1540-1413
Publisher:
National Comprehensive Cancer Network
Cover Journal of the National Comprehensive Cancer Network
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Copyright:
Copyright © 2007 by the National Comprehensive Cancer Network
Page Numbers:
8
Article Category:
Research Article
Received:
12 Jun 2007
Accepted:
19 Jun 2007
Print Publication Date:
01 Oct 2007
Online Publication Date:
Oct 2007
Keywords:
Targeted therapy; metastatic colon cancer; chemotherapy

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