Breast cancer is the most commonly diagnosed cancer in American women, with an estimated 214,640 cases and 41,430 deaths occurring in 2006. Estimating breast cancer risk for individual women is difficult, and most breast cancers are not attributable to risk factors other than female gender and increased age. Developing effective strategies for reducing breast cancer incidence is also difficult because few existing risk factors are modifiable and some potentially modifiable risk factors have social implications. Nevertheless, effective breast cancer risk reduction agents and strategies, such as tamoxifen, raloxifene, and risk reduction surgery, have been identified. These guidelines were developed to help women at increased risk for breast cancer and their physicians apply individualized strategies to reduce breast cancer risk.

For the most recent version of the guidelines, please visit

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The Robert H. Lurie Comprehensive Cancer Center of Northwestern University ( is the only NCI-designated comprehensive cancer center in Illinois. It is dedicated to scientific discovery, advancing medical knowledge, providing compassionate, state-of-the-art cancer care, and training the next generation of clinicians and scientists.

The Cancer Center and its affiliated hospitals and practices annually treat more than 10,000 new cancer cases, providing an extensive range of treatment and clinical trial options. On the main campus in downtown Chicago, 72 inpatient medical oncology beds will move into the new Prentice Women's Hospital in October, 2007 (third picture on cover). In addition to the new medical oncology rooms, there will be inpatient gynecology beds and expanded outpatient space dedicated to women's cancers and a women's radiation oncology center. This space complements the 32,000 net square foot (NSF) outpatient Cancer Center.

The research efforts of the Cancer Center's 230 members are organized into 10 major programs and annually generate more than $115 in cancer-relevant, extramural funding. A dedicated research facility supports these efforts. In 2005, the Cancer Center occupied 60,000 NSF of laboratory space with the dedication of the 12-story Robert H Lurie Medical Research Center.

Cancer Center director Steven T Rosen, MD, FACP (second photo on cover), is a nationally recognized clinical scientist whose research is focused on biologic therapies of hematologic malignancies. He has published more than 200 peer-reviewed articles and has received recognition from the oncology community.

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