Counterpoint: The Argument for Combination Chemotherapy in the Treatment of Metastatic Breast Cancer

Authors:
Mary Cianfrocca From Northwestern University, Feinberg School of Medicine, Chicago, Illinois.

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William J. Gradishar From Northwestern University, Feinberg School of Medicine, Chicago, Illinois.

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Volume/Issue:
Volume 5: Issue 8
Online Publication Date:
Sep 2007
DOI:
https://doi.org/10.6004/jnccn.2007.0069
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The question of combination versus single-agent chemotherapy in the setting of metastatic breast cancer (MBC) is an often-debated issue. Many single agents have activity in this setting and the potential for significant synergism between chemotherapy agents has led to many combination chemotherapy trials. This article defends the position that combination chemotherapy is the optimal approach for patients with MBC.

Correspondence: William J. Gradishar, MD, Northwestern University, Feinberg School of Medicine, 676 North St. Clair, Suite 850, Chicago, IL 60611. E-mail: w-gradishar@northwestern.edu
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Copyright:
Copyright © 2007 by the National Comprehensive Cancer Network
Page Numbers:
3
Article Category:
Research Article
Received:
19 Apr 2007
Accepted:
21 May 2007
Print Publication Date:
01 Sep 2007
Online Publication Date:
Sep 2007
Keywords:
Metastatic breast cancer; single agent; combination therapy; chemotherapy; polychemotherapy
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