Photodynamic Therapy for Non-Melanoma Skin Cancer

Authors: Sari M. Fien MD1 and Allan R. Oseroff MD, PhD1
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  • 1 From the Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York.

Photodynamic therapy (PDT) involves the administration of a photosensitizing drug and its subsequent activation by light at wave-lengths matching the absorption spectrum of the photosensitizer. Because the skin is readily accessible to light-based therapies, PDT with systemic and particularly with topical agents has become important in treating cutaneous disorders. Topical PDT is indicated for treating actinic keratosis, superficial or thin non-melanoma skin cancer, including some cases of nodular basal cell carcinoma, and some cutaneous lymphomas. Advantages of aminolevulinic acid/methyl aminolevulinate PDT include the possibility of simultaneous treatment of multiple tumors and large surface areas, good cosmesis, and minimal morbidity, such as bleeding, scarring, or infection.

Correspondence: Allan R. Oseroff, MD, PhD, Roswell Park Cancer Institute and State University of NY at Buffalo, Elm & Carlton Streets, Buffalo, NY 14263. E-mail: allan.oseroff@roswellpark.org
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