Chronic Myelogenous Leukemia Guidelines

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Chronic myelogenous leukemia (CML) accounts for 15% of adult leukemias. In 2007, an estimated 4500 cases will be diagnosed and 900 patients will die of the disease. The goal of CML therapy is complete remission, which typically progresses from hematologic to cytogenetic remission. These updated 2007 guidelines include changes to several treatment recommendations, including considerations for imatinib dosing, the use of interferon, and management of dasatinib toxicity. Recommendations for hematopoetic stem cell transplantation have also been updated.

For the most recent version of the guidelines, please visit

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Vanderbilt-Ingram Cancer Center (VICC; is one of a select few NCI-designated centers in the Southeast and the only NCI-designated Comprehensive Cancer Center in Tennessee. Established under the leadership of Dr. Harold Moses in 1993, VICC brings together the cancer-related research, clinical care, education, prevention, and outreach activities at Vanderbilt University and Medical Center.

VICC's 250 faculty members in 7 research programs generate more than $135 million in research support from public and private sources. VICC focuses its efforts on high-impact basic and translational research and high quality multidisciplinary care, with particularly strong programs in phase I clinical trials, and lung, gastrointestinal, breast, head and neck, melanoma, pediatric, and hematologic malignancies. Its collaborative research initiatives include 3 Specialized Programs of Research Excellence, the Southern Community Cohort Study, and a U54 minority partnership with Meharry Medical College.

The center is led by interim director Jennifer A. Pietenpol, PhD (second photo on cover), Ingram Professor of Cancer Research, a biochemist with a research focus on tumor suppressor and cell cycle checkpoint signaling pathways. For more information about clinical trials, services, or second opinion consultation at VICC, call (800) 811-8480.

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