Pathology of Soft Tissue Sarcoma

The evaluation and treatment of soft tissue sarcomas has never been more demanding than it is today. The pathologist plays a central role in this process and is an integral member of the multidisciplinary sarcoma treatment team. This article provides a brief summary of the role of the soft tissue pathologist and includes sections on methods of diagnosis, frozen section, classification of sarcomas, expert consultation, molecular pathology, grading, assessment of treatment response, and tumor banking.

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Correspondence: Brian P. Rubin, MD, PhD, Departments of Anatomic Pathology and Molecular Genetics, Lerner Research Institute and Taussig Cancer Center, Cleveland Clinic Foundation, L25, 9500 Euclid Avenue, Cleveland, OH 44195. E-mail: rubinb2@ccf.org
  • 1.

    SinghHKKilpatrickSESilvermanJF. Fine needle aspiration biopsy of soft tissue sarcomas: utility and diagnostic challenges. Adv Anat Pathol2004;11:2437.

    • Search Google Scholar
    • Export Citation
  • 2.

    YangYJDamronTA. Comparison of needle core biopsy and fine-needle aspiration for diagnostic accuracy in musculoskeletal lesions. Arch Pathol Lab Med2004;128:759764.

    • Search Google Scholar
    • Export Citation
  • 3.

    HoeberISpillaneAJFisherCThomasJM. Accuracy of biopsy techniques for limb and limb girdle soft tissue tumors. Ann Surg Oncol2001;8:8087.

    • Search Google Scholar
    • Export Citation
  • 4.

    WHO classification of tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press; 2002.

  • 5.

    LadanyiMBridgeJA. Contribution of molecular genetic data to the classification of sarcomas. Hum Pathol2000;31:532538.

  • 6.

    TomescuOBarrFG. Chromosomal translocations in sarcomas: prospects for therapy. Trends Mol Med2001;7:554559.

  • 7.

    BarrFGZhangPJ. The impact of genetics on sarcoma diagnosis: an evolving science. Clin Cancer Res2006;12:52565257.

  • 8.

    ArbiserZKFolpeALWeissSW. Consultative (expert) second opinions in soft tissue pathology. Analysis of problem-prone diagnostic situations. Am J Clin Pathol2001;116:473476.

    • Search Google Scholar
    • Export Citation
  • 9.

    BordenECBakerLHBellRS. Soft tissue sarcomas of adults: state of the translational science. Clin Cancer Res2003;9:19411956.

  • 10.

    AntonescuCR. The role of genetic testing in soft tissue sarcoma. Histopathology2006;48:1321.

  • 11.

    BinhMBSastre-GarauXGuillouL. MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol2005;29:13401347.

    • Search Google Scholar
    • Export Citation
  • 12.

    JacobEKErickson-JohnsonMWangX. Assessment of MDM2 amplification using fluorescence in situ hybridization on paraffin embedded tissues discriminates atypical lipomatous tumor from lipomas. Mod Pathol2006;19:13A.

    • Search Google Scholar
    • Export Citation
  • 13.

    RubinBP. Gastrointestinal stromal tumors: an update. Histopathology2006;48:8396.

  • 14.

    OttaianoADe ChiaraAFazioliF. Biological prognostic factors in adult soft tissue sarcomas. Anticancer Res2005;25:45194526.

  • 15.

    NielsenTO. Microarray analysis of sarcomas. Adv Anat Pathol2006;13:166173.

  • 16.

    WestRBCorlessCLChenX. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT and PDGFRA mutation status. Am J Pathol2004;165:107113.

    • Search Google Scholar
    • Export Citation
  • 17.

    DuensingAJosephNEMedeirosF. Protein kinase C theta (PKCtheta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs). Cancer Res2004;64:51275131.

    • Search Google Scholar
    • Export Citation
  • 18.

    TerryJSaitoTSubramanianS. TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies. Am J Surg Pathol2007;31:240246.

    • Search Google Scholar
    • Export Citation
  • 19.

    OliveiraAMNascimentoAG. Grading in soft tissue tumors: principles and problems. Skeletal Radiol2001;30:543559.

  • 20.

    DeyrupATWeissSW. Grading of soft tissue sarcomas: the challenge of providing precise information in an imprecise world. Histopathology2006:48;4250.

    • Search Google Scholar
    • Export Citation
  • 21.

    CoindreJMTrojaniMContessoG. Reproducibility of a histopathologic grading system for adult soft tissue sarcoma. Cancer1986;58:306309.

    • Search Google Scholar
    • Export Citation
  • 22.

    CostaJWesleyRAGlatsteinERosenbergSA. The grading of soft tissue sarcomas. Results of a clinicohistopathologic correlation in a series of 163 cases. Cancer1984;53:530541.

    • Search Google Scholar
    • Export Citation
  • 23.

    GuillouLCoindreJMBonichonF. Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma. J Clin Oncol1997;15:350362.

    • Search Google Scholar
    • Export Citation
  • 24.

    RubinBPFletcherCDInwardsC. Protocol for the examination of specimens from patients with soft tissue tumors of intermediate malignant potential, malignant soft tissue tumors, and benign/locally aggressive and malignant bone tumors. Arch Pathol Lab Med2006;130:16161629.

    • Search Google Scholar
    • Export Citation
  • 25.

    CoindreJM. Grading of soft tissue sarcomas. Review and update. Arch Pathol Lab Med2006;130:14481453.

  • 26.

    HasegawaTYamamotoSYokoyamaR. Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk. Cancer2002;95:843851.

    • Search Google Scholar
    • Export Citation
  • 27.

    CoindreJMTerrierPGuillouL. Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: a study of 1240 patients from the French Federation of Cancer Centers Sarcoma Group. Cancer2001;91:19141926.

    • Search Google Scholar
    • Export Citation
  • 28.

    FarshidGPradhamMGoldblumJWeissSW. Leiomyosarcoma of soft tissues: a tumor of vascular origin with multivariate analysis of outcome in 42 cases. Am J Surg Pathol2002;26:1424.

    • Search Google Scholar
    • Export Citation
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