Phyllodes Tumors of the Breast: Natural History, Diagnosis, and Treatment

Authors:
Melinda L. Telli From the Departments of Medicine, Radiation Oncology, and Surgery, Stanford University, Stanford, California.

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,
Kathleen C. Horst From the Departments of Medicine, Radiation Oncology, and Surgery, Stanford University, Stanford, California.

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Alice E. Guardino From the Departments of Medicine, Radiation Oncology, and Surgery, Stanford University, Stanford, California.

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,
Frederick M. Dirbas From the Departments of Medicine, Radiation Oncology, and Surgery, Stanford University, Stanford, California.

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Robert W. Carlson From the Departments of Medicine, Radiation Oncology, and Surgery, Stanford University, Stanford, California.

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Volume/Issue:
Volume 5: Issue 3
Online Publication Date:
Mar 2007
DOI:
https://doi.org/10.6004/jnccn.2007.0027
Full access

Phyllodes tumors of the breast are unusual fibroepithelial tumors that exhibit a wide range of clinical behavior. These tumors are categorized as benign, borderline, or malignant based on a combination of histologic features. The prognosis of phyllodes tumors is favorable, with local recurrence occurring in approximately 15% of patients overall and distant recurrence in approximately 5% to 10% overall. Wide excision with a greater than 1 cm margin is definitive primary therapy. Adjuvant systemic therapy is of no proven value. Patients with locally recurrent disease should undergo wide excision of the recurrence with or without subsequent radiotherapy.

Correspondence: Robert W. Carlson, MD, 875 Blake Wilbur Drive, Stanford, CA 94305. E-mail: rcarlson@stanford.edu
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Copyright:
Copyright © 2007 by the National Comprehensive Cancer Network
Page Numbers:
7
Article Category:
Research Article
Received:
02 Nov 2006
Accepted:
20 Nov 2006
Print Publication Date:
01 Mar 2007
Online Publication Date:
Mar 2007
Keywords:
Phyllodes tumors; breast neoplasms; natural history; diagnosis; treatment
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