NCCN Invasive Breast Cancer Clinical Practice Guidelines in Oncology

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
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The American Cancer Society estimates that 214,640 new cases of breast cancer will be diagnosed and 41,430 will die of the disease in the United States in 2006. Breast cancer is the most common malignancy in women in the United States and is second only to lung cancer as a cause of cancer death. The incidence of breast cancer has steadily increased in the United States over the past few decades, but breast cancer mortality appears to be declining, suggesting a benefit from early detection and more effective treatment. These guidelines discuss diagnosis, treatment, and follow up for invasive breast cancer.

For the most recent version of the guidelines, please visit

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (SKCCC) ( is dedicated to better understanding of human cancers and translating biologic research to the clinic. It is the only NCI-designated comprehensive cancer center in Maryland.

During the past 15 years under the leadership of Martin Abeloff, MD (second photo on cover), the Center has undergone significant growth in research funding, faculty recruitment, and new facilities. Since 1992, the faculty has increased in size from 142 members with $24.2 million in research funding to 220 members with research funds totaling $145.7 million. The Center has seven SPORE (Specialized Programs of Research Excellence) grants from the National Cancer Institute in breast, lung, prostate, cervical cancer, gastrointestinal, lymphoma, and head and neck cancers. The Cancer Center also has expanded into 3 new buildings—1 dedicated to clinical care and 2 others for laboratory research—comprising nearly one million square fee of space.

Martin Abeloff plans to step down as director later this year, and a national search is under way. Dr. Abeloff will remain as head of the Center until the new director is hired.

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