Chemotherapy-induced neutropenia can cause complications that result in dose reductions or treatment delays that can, in turn, compromise clinical outcomes. Although the prophylactic use of colony-stimulating factors (CSFs) can reduce the risk, severity, and duration of severe and febrile neutropenia, they are not routinely administered to all patients undergoing myelosuppressive chemotherapy because of the costs. Selective use may, however, enhance their cost-effectiveness. These guidelines discuss the preventative or prophylactic use of recombinant human granulocyte-CSF to reduce the incidence, length, and severity of chemotherapy-related neutropenia and and prevent life-threatening complications.
For the most recent version of the guidelines, please visit NCCN.org
Huntsman Cancer Institute (HCI; huntsmancancer.org) at the University of Utah is the only NCI-designated cancer center in the Intermountain West, serving Utah, Nevada, Idaho, Montana, and Wyoming. HCI acts as steward of the Utah Population Database, the largest genetic database in the world. This resource was pivotal in the discovery of several genes implicated in cancer, including BRCA1, BRCA2, APC, and p16. HCI research includes laboratory studies, clinical research, and population studies. HCI's 50-bed cancer specialty hospital and outpatient clinics provide patient care using a multidisciplinary approach to diagnosis and treatment. HCI is the only cancer research hospital in the country that offers patients a comprehensive fitness program, part of its Wellness Center, which also provides nutritional advice and support groups for cancer patients and their caregivers. Walk-in, telephone, online, and outreach programs provide cancer prevention, screening, and treatment information for patients, their families, and the public.
Executive Director Mary Beckerle, PhD, is a nationally-recognized cell biologist whose HCI laboratory has discovered and characterized pathways that control cell motility, adhesion, and response to environmental cues. She holds the Ralph E. and Willia T. Main Presidential Endowed Chair in Cancer Research at the University of Utah and has served as president of the American Society of Cell Biology.