Cancer-Related Fatigue

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Fatigue is a common symptom in patients with cancer and is nearly universal in those undergoing cytotoxic chemotherapy, radiation therapy, bone marrow transplantation, or treatment with biologic response modifiers. The problem, which affects 70% to 100% of cancer patients, has been exacerbated by the increased use of fatigue-inducing multimodal treatments and dose-dense, dose-intense protocols. In patients with metastatic disease, the prevalence of cancer-related fatigue exceeds 75%, and cancer survivors report that fatigue is a disruptive symptom months or even years after treatment ends. Patients perceive fatigue to be the most distressing symptom associated with cancer and its treatment, more distressing even than pain or nausea and vomiting, which, for most patients, can generally be managed with medications.

For the most recent version of the guidelines, please visit NCCN.org

Known worldwide for its expertise in the diagnosis and treatment of pediatric cancers, St. Jude Children's Research Hospital (www.stjude.org) is dedicated to saving children's lives by finding the causes of catastrophic illnesses, improving treatment, and developing cures. St. Jude is internationally known for its treatment of all pediatric cancers, but is particularly esteemed for its treatment of brain tumors, leukemia, lymphoma, neuroblastoma, osteosarcoma, and retinoblastoma. St. Jude oncologists are also experts in gene therapy and pediatric stem cell transplantation. Founded by late entertainer Danny Thomas and based in Memphis, Tennessee, St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit the web site.

William E. Evans, PharmD (second photo), assumed the position of St. Jude Director and CEO in 2004. Previously the hospital's scientific director, Dr. Evans has published more than 250 research articles and has received 3 MERIT Awards from the National Institutes of Health for his research.

Michael Kastan, MD, PhD (third photo), is the director of the St. Jude Cancer Center. Dr. Kastan's laboratory is making major strides in elucidating how DNA damage affects cancer development.

St. Jude works in partnership with University of Tennessee and the University of Tennessee Cancer Institute.

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