Rational Use of Cytotoxic Chemotherapy for Recurrent Ovarian Cancer

Authors: Joyce Liu MD1 and Ursula Matulonis MD1
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  • 1 From the Department of Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

Ovarian cancer remains the leading cause of death among women with gynecologic malignancies, and the fifth leading cause of cancer mortality in women in the United States. Although many patients respond to first-line platinum-based therapy, most will experience disease recurrence. The role of further therapy in the setting of recurrent ovarian cancer is palliative, and large randomized phase III trials on treatment options for recurrent ovarian cancer are rare. Controversies exist as to the optimal timing and duration of treatment, and many issues regarding treatment of recurrent disease remain.

Correspondence: Ursula Matulonis, MD, Department of Oncology, Dana-Farber Cancer Institute, Dana Building, 44 Binney Street, Boston, MA 02115. E-mail: ursula_matulonis@dfci.harvard.edu
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