Current Approaches in Familial Colorectal Cancer: A Clinical Perspective

Author:
Patrick M. LynchFrom The University of Texas M. D. Anderson Cancer Center, Houston, Texas.

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Volume/Issue:
Volume 4: Issue 4
Online Publication Date:
Apr 2006
DOI:
https://doi.org/10.6004/jnccn.2006.0034
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Individuals with a family history of colorectal cancer or colorectal adenomas have an increased risk for colorectal cancer. When no hereditary syndrome is evident, screening is based on empiric risk estimates. The risk is greatest for individuals with specific inherited cancer-predisposing disorders. When conditions such as familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer are diagnosed, specific neoplasm risk estimates can usually be performed based on advances in molecular genetics. These estimates lead to more straightforward and cost-effective approaches to surveillance and management. The National Comprehensive Cancer Center Network (NCCN) and other groups have provided detailed guidelines for evaluating patients based on recognition of clinical syndrome characteristics, followed by appropriate genetic counseling, genetic testing, and optimal surveillance. The NCCN guidelines are used as a frame of reference for this discussion of selected recent advances in human cancer genetics as they apply to clinical practice.

Correspondence: Patrick M. Lynch, JD, MD, Associate Professor of Medicine, Department of Gastrointestinal Medicine and Nutrition - 436, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030. E-mail: plynch@mdanderson.org
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Copyright:
Copyright © 2006 by the National Comprehensive Cancer Network
Page Numbers:
10
Article Category:
Research Article
Received:
12 Oct 2005
Accepted:
28 Oct 2005
Print Publication Date:
01 Apr 2006
Online Publication Date:
Apr 2006
Keywords:
Hereditary colon cancer; genetic testing; adenoma surveillance
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