Esophageal Cancer Clinical Practice Guidelines

City of Hope Cancer Center
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Carcinomas originating in the upper gastrointestinal (GI) tract (esophagus, gastroesophageal junction, and stomach) constitute a worldwide major health problem. Unfortunately, esophageal carcinoma is often diagnosed late, and most therapeutic approaches are palliative, although advances have been made in staging procedures and therapy. The guidelines emphasize that palpable advances have been made in the treatment of locoregional esophageal carcinoma. Similarly, endoscopic palliation of esophageal carcinoma has improved substantially because of improving technology.

For the most recent version of the guidelines, please visit

City of Hope (COH) is a leading biomedical research and treatment center and 1 of only 3 National Cancer Institutedesignated Comprehensive Cancer Centers in Los Angeles County. COH has achieved numerous scientific breakthroughs, impacting treatment worldwide.

  1. COH conducts more than 300 clinical studies, involving 30% to 40% of its eligible patients, well above the national average.
  2. COH has performed more than 7,000 bone marrow and stem cell transplants and today runs one of the largest programs in the world.
  3. Numerous lifesaving drugs are based on COH research, including trastuzumab, rituximab, and bevacizumab.
  4. COH routinely performs among the highest number of laparoscopic prostatectomies in the U.S.
  5. Physicians at COH performed the world's first total marrow irradiation procedure using TomoTherapy technology, and surgeons here were among the first to use robotic technology to treat cancer.
  6. COH is the only institution in the world with a clinical study using genetically engineered T-cells to recognize and attack glioma.

Theodore G. Krontiris, MD, PhD (second picture on cover), is Director of the COH Cancer Center and Executive VP, Medical and Scientific Affairs. He serves on numerous advisory panels, including the NIH and NCI, and he is on the board of directors for NCCN.

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