An estimated 61,420 new cases of urinary bladder cancer will be diagnosed in the United States in 2006, making it the fourth most common cancer in men and the ninth most common neoplasm in women. Because the median age of diagnosis is 65 years, medical comorbidities are a frequent consideration. The clinical spectrum of bladder cancer can be divided into 3 categories: noninvasive tumors, invasive lesions, and metastatic lesions. These categories differ in prognosis, management, and therapeutic goals, and these guidelines discuss management strategies to achieve the best possible outcomes.

For the most recent version of the guidelines, please visit NCCN.org

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The University of Nebraska Medical Center (UNMC) Eppley Cancer Center (www.unmc.edu/cancercenter) is a partnership of UNMC, the Eppley Institute for Cancer, and The Nebraska Medical Center.

The Center integrates research and education with patient care to offer the most up-to-date treatments for a variety of cancers. This unique collaboration between The Nebraska Medical Center cancer physicians and UNMC researchers allows discoveries made in the laboratories to be taken directly to the patient.

A National Cancer Institute-designated Clinical Cancer Center and founding member of the National Comprehensive Cancer Network (NCCN), the Center has extensive interdisciplinary research and therapy programs in lymphoma, stem cell transplantation, gastrointestinal and pancreatic cancer, prostate cancer, breast cancer, and aerodigestive cancers.

Center Director Kenneth H. Cowan, MD, PhD (second photo on cover), is a leading breast cancer clinician and researcher. He joined the Center in 1999 after 21 years with the National Cancer Institute.

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