An estimated 38,890 Americans will be diagnosed with kidney cancer and 12,840 will die of this disease in the United States in 2006. Renal cell carcinoma (RCC) constitutes approximately 2% of all malignancies, with a median age at diagnosis of 65 years. Smoking and obesity are among the risk factors for RCC development, and tumor grade, local extent of the tumor, presence of regional nodal metastases, and evidence of metastatic disease at presentation are the most important prognostic determinants of 5-year survival. These guidelines discuss evaluation, staging, treatment, and management after treatment.

For the most recent version of the guidelines, please visit NCCN.org

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The University of Nebraska Medical Center (UNMC) Eppley Cancer Center (www.unmc.edu/cancercenter) is a partnership of UNMC, the Eppley Institute for Cancer, and The Nebraska Medical Center.

The Center integrates research and education with patient care to offer the most up-to-date treatments for a variety of cancers. This unique collaboration between The Nebraska Medical Center cancer physicians and UNMC researchers allows discoveries made in the laboratories to be taken directly to the patient.

A National Cancer Institute-designated Clinical Cancer Center and founding member of the National Comprehensive Cancer Network (NCCN), the Center has extensive interdisciplinary research and therapy programs in lymphoma, stem cell transplantation, gastrointestinal and pancreatic cancer, prostate cancer, breast cancer, and aerodigestive cancers.

Center Director Kenneth H. Cowan, MD, PhD (second photo on cover), is a leading breast cancer clinician and researcher. He joined the Center in 1999 after 21 years with the National Cancer Institute.

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