Developmental Therapeutics for Myelodysplastic Syndromes

Authors:
Aung Naing From H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida, College of Medicine, Tampa, Florida.

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 MD
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Lubomir Sokol From H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida, College of Medicine, Tampa, Florida.

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 MD, PhD
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Alan F. List From H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida, College of Medicine, Tampa, Florida.

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Volume/Issue:
Volume 4: Issue 1
Online Publication Date:
Jan 2006
DOI:
https://doi.org/10.6004/jnccn.2006.0008
Full access

The management strategy for patients with myelodysplastic syndromes (MDS) has evolved from sole reliance on supportive measures to active treatment guided by disease risks. Recent progress in understanding the molecular pathogenesis of MDS has accelerated the discovery of new therapeutic targets, and consequently launched the development of several novel therapeutics that are currently in varied stages of clinical testing. One such agent is lenalidomide, which has shown remarkable effectiveness in the cytogenetically defined subset of MDS with the chromosome 5q31 deletion. The advent of new and effective targeted therapeutics may beneficially affect outcomes of an ever-increasing number of patients with MDS. This discussion summarizes the preliminary results of selected novel therapeutics.

Correspondence: Alan List, MD, Chief, Division of Malignant Hematology, 12902 Magnolia Drive, SRB-4, Tampa, FL 33612-9497. E-mail: listaf@moffitt.usf.edu
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Print ISSN:
1540-1405
Online ISSN:
1540-1413
Publisher:
National Comprehensive Cancer Network
Cover Journal of the National Comprehensive Cancer Network
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Copyright:
Copyright © 2006 by the National Comprehensive Cancer Network
Page Numbers:
5
Article Category:
Research Article
Received:
11 Aug 2005
Accepted:
28 Sep 2005
Print Publication Date:
01 Jan 2006
Online Publication Date:
Jan 2006
Keywords:
Myelodysplastic syndrome; targeted therapy; clinical trial

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