Partial-Breast Radiation for Early Staged Breast Cancers: Hypothesis, Existing Data, and a Planned Phase III Trial

Author:
Beryl McCormick Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York

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Volume/Issue:
Volume 3: Issue 3
Online Publication Date:
May 2005
DOI:
https://doi.org/10.6004/jnccn.2005.0017
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This review of clinical data from partial-breast treatment studies discusses results from a single institution's experience using brachytherapy catheters, the MammoSite balloon (Proxima Company, Alpharetta, GA), and three-dimensional external beam partial-breast treatment. Rationale, techniques, dose schedules, and available results are presented. Intra-operative single-dose radiation to the lumpectomy site is also reviewed. The National Surgical Adjuvant Breast and Bowel Project (NSABP) and Radiation Therapy Oncology Group (RTOG) cooperative groups are opening a phase III trial to compare partial-breast treatment to the standard 5- to 6-week course of whole-breast radiation. The design of this study is also presented in this review.

Correspondence: Beryl McCormick, MD, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021. E-mail: mccormib@mskcc.org
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Print ISSN:
1540-1405
Online ISSN:
1540-1413
Publisher:
National Comprehensive Cancer Network
Cover Journal of the National Comprehensive Cancer Network
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Copyright:
Copyright © 2005 by the National Comprehensive Cancer Network 2005
Page Numbers:
7
Article Category:
Research Article
Received:
28 Dec 2004
Accepted:
08 Feb 2005
Print Publication Date:
01 May 2005
Online Publication Date:
May 2005
Keywords:
Breast cancer; partial-breast irradiation; breast conservation

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