The NCCN Oncology Research Program (ORP) strives to improve the quality of life for patients and reduce cancer-related deaths by advancing cancer therapies through research. Since the program’s establishment in 1999, the NCCN ORP has brought millions of dollars in research grants to investigators at NCCN Member Institutions. Research grants are provided to NCCN through collaborations with pharmaceutical and biotechnology companies; these grants are in turn used to support scientifically meritorious cancer research efforts.
NCCN ORP studies typically explore new avenues of clinical investigation and seek answers to important cancer-related questions. All studies are approved and funded through a scientific peer-review process and are overseen by the ORP.
This feature highlights an NCCN study funded through the grant mechanism.
Contribution of Race to Nutritional Approach to Lower Cardiovascular Risk Factors in Men Undergoing Androgen Deprivation Therapy
Principal Investigator: Zhaoping Li, MD, PhD
Condition: Prostate cancer/quality study
Institution: UCLA
There is a well-documented association between androgen deprivation therapy (ADT) and cardiovascular morbidity. Most men receiving ADT gain weight, contributing to an increase in cardiovascular risk factors (CVRFs) and cardiovascular morbidity. Dietary intervention combined with exercise has shown success in reducing weight/fat mass and improving CVRFs. There are few data on whether African American men would respond to diet and exercise interventions differently than non-Hispanic white men.
Primary Objective/Aim:
• Compare effect of a hypocaloric, anti-inflammatory diet on changes in fat mass between African American and non-Hispanic White men with metastatic prostate cancer receiving ADT
Secondary Objectives/Aims:
• Compare effect of a hypocaloric, anti-inflammatory diet on changes in CVRFs (body weight, lean body mass, waist-to-height ratio, blood pressure, and lipid and HbA1c levels) and inflammatory markers (high-sensitivity C-reactive protein and cytokines) between African American and non-Hispanic White men with metastatic prostate cancer receiving ADT
Tertiary Objective/Aim:
• Compare effect of a hypocaloric, anti-inflammatory diet on changes in cancer-related fatigue and quality of life between African American and non-Hispanic White men with metastatic prostate cancer receiving ADT
Contacts: Zhaoping Li, MD, PhD • zli@mednet.ucla.edu
Gail Thames • gthames@mednet.ucla.edu
