The NCCN Oncology Research Program (ORP) strives to improve the quality of life for patients and reduce cancer-related deaths by advancing cancer therapies through research. Since the program’s establishment in 1999, the NCCN ORP has brought millions of dollars in research grants to investigators at NCCN Member Institutions. Research grants are provided to NCCN through collaborations with pharmaceutical and biotechnology companies; these grants are in turn used to support scientifically meritorious cancer research efforts.
NCCN ORP studies typically explore new avenues of clinical investigation and seek answers to important cancer-related questions. All studies are approved and funded through a scientific peer-review process and are overseen by the ORP.
This feature highlights an NCCN study funded through the grant mechanism.
Personalized Medical Treatment of Coronary Atherosclerosis in Prostate Cancer Patients Guided by Plaque Assessment With Quantitative Coronary CT Angiography
Principal Investigator: Suparna C. Clasen, MD, MSCE
Condition: Prostate cancer/quality study
Institution: Indiana University School of Medicine
This is a randomized pilot study of noninvasive coronary CT angiography (CCTA) for the detection of coronary artery plaque versus usual care in patients with prostate cancer who are either planning to begin or are currently taking androgen deprivation therapy (ADT). Subjects are randomized 1:1 to either the CCTA group or non-CCTA (usual care) group. Target enrollment will be 100 subjects.
Primary Objective/Aim:
• To use quantitative CCTA to (1) define the prevalence of atherosclerotic cardiovascular disease (ASCVD) in men with prostate cancer receiving ADT, and (2) identify gaps in optimal treatment of ASCVD and its risk factors in these patients
Secondary Objective/Aim:
• Demonstrate that CCTA-based plaque assessment followed by evidence-based treatments for ASCVD risk factors such hypertension, hyperlipidemia, and hyperglycemia will be associated with reduction in clinical and serologic markers that predict long-term risk of adverse cardiovascular events
Contacts: Nishant M. Chenchaiah • 317-278-0070 • nischenc@iu.edu
Suparna C. Clasen, MD, MSCE • 317-963-5462 • scclasen@iu.edu
ClinicalTrials.gov Identifier: NCT05879913
