Highlights of the NCCN Oncology Research Program

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The NCCN Oncology Research Program (ORP) strives to improve the quality of life for patients and reduce cancer-related deaths by advancing cancer therapies through research. Since the program’s establishment in 1999, the NCCN ORP has brought millions of dollars in research grants to investigators at NCCN Member Institutions. Research grants are provided to NCCN through collaborations with pharmaceutical and biotechnology companies; these grants are in turn used to support scientifically meritorious cancer research efforts.

NCCN ORP studies typically explore new avenues of clinical investigation and seek answers to important cancer-related questions. All studies are approved and funded through a scientific peer-review process and are overseen by the ORP.

This feature highlights an NCCN study funded through the grant mechanism.

CV CARE: CardioVascular Care of Androgen-Related Effects in Patients With Prostate Cancer

Principal Investigator: Alicia Morgans, MD, MPH

Condition: Prostate cancer—quality of care

Institution: Dana-Farber Cancer Institute

CV CARE is a trial enrolling patients undergoing treatment with androgen deprivation therapy (ADT) in order to assess and manage reversible cardiovascular (CV) risk factors. In this quality improvement initiative within the Dana-Farber Cancer Institute (DFCI) genitourinary oncology clinic, the clinical team will systematically leverage existing follow-up visits for prostate cancer care by integrating CV risk assessment, electronic medical record alerts and communications, and counseling to ensure improved adherence to guideline recommendations addressing reversible CV risk factors. The initiative also includes standardized communications with local cardiology care or seamless referral to cardio-oncology for the highest-risk patients who do not have known cardiac care providers. This research is being conducted to test a program to assess and manage reversible CV risk factors in participants with prostate cancer starting ADT, with the goal of integrating a standardized method into DFCI clinics for all such patients. After completing an initial iteration, the study will gather feedback from clinician and patient participants to identify areas for improvement. These changes will be made when feasible, and a second program, CV CARE 2, will be launched based on the learnings from the primary initiative.

Primary Objective/Aim:

  • • Determine the feasibility of integrating the revised CV CARE program (CV CARE 2) into the genitourinary oncology care workflow at DFCI. Feasibility of the program will be determined by a continued participation rate in the revised iteration of the program (CV CARE 2) of ≥75% of patients who participate at month 1.

Secondary Objectives:

  • • Quantify the proportion of patients who start or adjust statin medications between 1 month after ADT initiation and the 6-month follow-up visit among those who have an atherosclerotic CV disease (ASCVD) risk score >10% and 20% at month 1.

  • • Quantify the proportion of patients who start or adjust blood pressure medications between 1 month after ADT initiation and the 6-month follow-up visit among those who have an ASCVD risk score >10% and 20% at month 1.

  • • Compare the proportion of patients with average blood pressure <130/85 mm Hg after CV CARE (average of weeks 12 and 24) versus before CV CARE (average of ADT initiation and week 4).

  • • Assess patient-reported satisfaction with CV CARE visit location and duration, and clinician communication of CV risk factors.

  • • Assess clinician-reported satisfaction with frequency of engagement with local CV care teams, referrals to cardio-oncology, and CV CARE visit location and duration.

Contact: Alicia Morgans, MD, MPH • 857-215-1605 • aliciak_morgans@dfci.harvard.edu

ClinicalTrials.gov identifier: NCT06202820

For more information on specific trials, including patient selection criteria, use the contact information listed with each study.

For more information on the NCCN ORP, including a complete detailing of the clinical studies currently underway at NCCN Member Institutions, go to www.nccn.org/education-research/nccn-oncology-research-program/orp-main-page.

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