Background electronic health records (EHR) allowed physicians to access to patients informations in order to enhance the quality of care, a lot of studies has interested to the satisfaction and perception of oncology patients concerning EHR in many countries. In our knowledge this is the first Moroccan study on patients satisfaction with EHR in a university oncology center. Methods: A cross-sectional survey was conducted with patients who consulting in Mohammed VI oncology center. 297 patients were called to complete a structured questionnaire with multiple choice questions. Results: 189 patients answered questions, 175 women (92.59%) and 14 men (7.41%). 183 (96.8%) patients were satisfied because of improved communication and health care. The EHR also improved patient hospital course, 163 patients (86.24%) was satisfied from reception and relation with caregivers. 158 responders (83.6%) noticed that the consultation time was optimized after instauration of EHR and their informations were preserved. 81 patients (42.5%) preferred the presential check up. Conclusions: EHR had significantly improved the quality of care and confidentiality of records in Mohammed VI oncology center. our study evaluated the possibility of allowing patients to view their medical notes to achieve the goal of involving patients as active decision-makers in their own treatment. Based of the results of this study, EHR need to be generalized in all Moroccan hospitals.