Background: Chemotherapy and immunotherapy infusion reactions are common medical emergencies that occur in ambulatory infusion centers. It is common practice for institutions to have clinical hypersensitivity and infusion reaction protocols; however, there is not always a set standard of practice for documenting these critical events. Without a systematic approach to documenting these events, key information that captures the severity and nature of the infusion reaction can be missed and reactively compromise patient safety. This study proposes an electronic documentation tool for infusion nurses to use in practice, explores the importance of standardized documentation, and how it positively impacts interdisciplinary communication and patient safety. Methods: The author of this study created an electronic documentation tool for chemotherapy certified nurses to use in an infusion center located at an academic-based National Cancer Institute (NCI) designated cancer center. A survey was provided to the infusion nurses before and after implementing the tool into a live-practice setting. Results: Final data analysis is pending; however, survey results are anticipated to reflect an improvement in documentation practice, nursing workflow, interdisciplinary electronic communication, and overall patient safety. Conclusions: Pending analysis.