Role of Complexed PSA in the Early Detection of Prostate Cancer

Authors:
Yoshio NayaFrom the Department of Urology, Matsushita Memorial Hospital, Osaka, and the Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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 MD, PhD
and
Koji OkiharaFrom the Department of Urology, Matsushita Memorial Hospital, Osaka, and the Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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 MD, PhD
Volume/Issue:
Volume 2: Issue 3
Online Publication Date:
May 2004
DOI:
https://doi.org/10.6004/jnccn.2004.0019
Full access

Prostate cancer is a clinically significant health care problem in the United States. Total prostate specific antigen (tPSA) is widely used to detect prostate cancer with a significant increase in the incidence of organ-confined disease at the time of diagnosis. The limitations of tPSA are low specificity and positive predictive value. Numerous attempts to enhance PSA's performance based on prostate volume, patient age, patient race, and PSA velocity have shown little clinical improvement. Percent free PSA has proven to be somewhat improved but still limited. Recently, the complexed PSA (cPSA) assay was developed and multisite institutional studies have shown that cPSA has improved specificity over tPSA. Complexed PSA can replace tPSA as a first screening test.

Correspondence: Yoshio Naya, MD, PhD, Department of Urology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kyoto, Japan, 602-8566. E-mail: yoshionaya@hotmail.com
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Copyright:
Copyright © 2004 by the National Comprehensive Cancer Network 2004
Page Numbers:
4
Article Category:
Research Article
Received:
06 Jan 2004
Accepted:
19 Feb 2004
Print Publication Date:
01 May 2004
Online Publication Date:
May 2004
Keywords:
Prostate; prostatic neoplasm; detection; prostate-specific antigen; complexed PSA
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