Surgery in the Management of Small Cell Lung Cancer

Authors:
Robert J. DowneyFrom the Division of Thoracic Surgery, Department of Surgery, and Division of Thoracic Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.

Search for other papers by Robert J. Downey in
Current site
Google Scholar
PubMed
Close
 MD
and
Lee M. KrugFrom the Division of Thoracic Surgery, Department of Surgery, and Division of Thoracic Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.

Search for other papers by Lee M. Krug in
Current site
Google Scholar
PubMed
Close
 MD
Full access

Because most patients with small cell cancer of the lung present with distant metastatic disease, the treatment is almost always medical therapies without surgery. However, a small number of patients present with resectable disease, and this review summarizes the available literature addressing the possible role for surgery in the treatment of these patients.

Correspondence: Robert Downey, MD, Division of Thoracic Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021. E-mail: downeyr@mskcc.org
  • Collapse
  • Expand
  • 1

    Shepherd FA. Surgical management of small cell lung cancer. In: Pass HI, Mitchell JB, Johnson DH, eds. Lung Cancer: Principles and Practice. Philadelphia, PA: Lippincott Williams and Wilkins, 2000.

    • Search Google Scholar
    • Export Citation
  • 2

    Passlick B. Can surgery improve local control in small cell lung cancer? Lung Cancer 2001;33(Suppl 1):S147S151.

  • 3

    Kohman LJ. Is there a place for surgery in central small cell lung cancer? Chest Surg Clin N Am 1997;7:105112.

  • 4

    Lassen U, Hansen HH. Surgery in limited stage small cell lung cancer. Cancer Treat Rev 1999;25:6772.

  • 5

    Szczesny TJ, Szczesna A, Shepherd FA et al.. Surgical treatment of small cell lung cancer. Semin Oncol 2003;30:4756.

  • 6

    Martini N, Wittes RE, Hilaris BS et al.. Oat cell carcinoma of the lung. Clin Bull 1975;5:144148.

  • 7

    Mountain CF. Clinical biology of small cell carcinoma: relationship to surgical therapy. Semin Oncol 1978;5:272279.

  • 8

    Fox W, Scadding JG. Medical Research Council comparative trial of surgery and radiotherapy for primary treatment of small-celled or oat-celled carcinoma of the bronchus: Ten-year follow-up. Lancet 1973;2:6365.

    • Search Google Scholar
    • Export Citation
  • 9

    Deslauriers J. Surgery for small cell lung cancer. [Review] Lung Cancer 1997;17(Suppl 1):S91S98.

  • 10

    Prasad US, Naylor AR, Walker WS et al.. Long-term survival after pulmonary resection for small cell carcinoma of the lung [comment]. Thorax 1989; 44:784787.

    • Search Google Scholar
    • Export Citation
  • 11

    Shah SS, Thompson J, Goldstraw P. Results of operation without adjuvant therapy in the treatment of small cell lung cancer. Ann Thorac Surg 1992;54:498501.

    • Search Google Scholar
    • Export Citation
  • 12

    Coolen L, Van den Eeckhout A, Deneffe G et al.. Surgical treatment of small cell lung cancer. Eur J Cardio-Thorac Surg 1995;9:5964.

  • 13

    Shepherd FA, Evans WK, Feld R et al.. Adjuvant chemotherapy following surgical resection for small-cell carcinoma of the lung. J Clin Oncol 1988;6:832838.

    • Search Google Scholar
    • Export Citation
  • 14

    Shepherd FA, Ginsberg RJ, Feld R et al.. Surgical treatment for limited small-cell lung cancer. The University of Toronto Lung Oncology Group Experience. J Thor Cardiovasc Surg 1991;101:385393.

    • Search Google Scholar
    • Export Citation
  • 15

    Karrer K, Ulsperger E. Surgery for cure followed by chemotherapy in small cell carcinoma of the lung. For the ISC-Lung Cancer Study Group. Acta Oncol 1995;34:899906.

    • Search Google Scholar
    • Export Citation
  • 16

    Prager RL, Foster JM, Hainesworth JD et al.. The feasibility of adjuvant surgery in limited-stage small cell carcinoma: A prospective evaluation. Ann Thorac Surg 1984;38:622626.

    • Search Google Scholar
    • Export Citation
  • 17

    Shepherd FA, Ginsberg RJ, Patterson GA et al.. A prospective study of adjuvant surgical resection after chemotherapy for limited small cell lung cancer. A University of Toronto Lung Oncology Group study. J Thor Cardiovasc Surg 1989;97:177186.

    • Search Google Scholar
    • Export Citation
  • 18

    Zatopek NK, Holoye PY, Ellerbroek NA et al.. Resectability of small-cell lung cancer following induction chemotherapy in patients with limited disease (stage II-IIIb). Am J Clin Oncol 1991;14:427432.

    • Search Google Scholar
    • Export Citation
  • 19

    Fujimori K, Yokoyama A, Kurita Y et al.. A pilot phase 2 study of surgical treatment after induction chemotherapy for resectable stage I to IIIA small cell lung cancer. Chest 1997;111:10891093.

    • Search Google Scholar
    • Export Citation
  • 20

    Inoue M, Nakagawa K, Fujiwara K et al.. Results of preoperative mediastinoscopy for small cell lung cancer. Ann Thorac Surg 2000;70:16201623.

  • 21

    Pignon JP, Arriagada R, Ihde DC et al.. A meta-analysis of thoracic radiotherapy for small-cell lung cancer [comment]. N Engl J Med 1992;327:16181624.

    • Search Google Scholar
    • Export Citation
  • 22

    Turrisi AT 3rd, Kim K, Blum R et al.. Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide [comment]. N Engl J Med 1999;340:265271.

    • Search Google Scholar
    • Export Citation
  • 23

    Lad T, Piantadosi S, Thomas P et al.. A prospective randomized trial to determine the benefit of surgical resection of residual disease following response of small cell lung cancer to combination chemotherapy. Chest 1994;106(Suppl 6):320S323S.

    • Search Google Scholar
    • Export Citation
  • 24

    Hirsch FR, Matthews MJ, Aisner S et al.. Histopathologic classification of small cell lung cancer. Changing concepts and terminology. Cancer 1988;62:973977.

    • Search Google Scholar
    • Export Citation
  • 25

    Shepherd FA, Ginsberg R, Patterson GA et al.. Is there ever a role for salvage operations in limited small-cell lung cancer? [comment]. J Thor Cardiovasc Surg 1991;101:196200.

    • Search Google Scholar
    • Export Citation
  • 26

    Hage R, Elbers JR, Brutel de la Riviere A et al.. Surgery for combined type small cell lung carcinoma. Thorax 1998;53:450453.

  • 27

    Quoix E, Fraser R, Wolkove N et al.. Small cell lung cancer presenting as a solitary pulmonary nodule. Cancer 1990;66:577582.

  • 28

    Lassen U, Osterlind K, Hansen M et al.. Long-term survival in small-cell lung cancer: post-treatment characteristics in patients surviving 5 to 18+ years: an analysis of 1,714 consecutive patients. J Clin Oncol 1995;13:12151220.

    • Search Google Scholar
    • Export Citation
  • 29

    Johnson BE, Linnoila RI, Williams JP et al.. Risk of second aerodigestive cancers increases in patients who survive free of small-cell lung cancer for more than 2 years. J Clin Oncol 1995;13:101111.

    • Search Google Scholar
    • Export Citation
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 125 37 2
PDF Downloads 119 51 2
EPUB Downloads 0 0 0