We wish to thank Yiting Zhou, postgraduate student in the Department of Epidemiology, School of Public Health, Medical College of Soochow University, and Yueping Shen, professor and director of the Department of Epidemiology, School of Public Health, Medical College of Soochow University, for providing statistical support. We also wish to thank Hang Su, doctoral candidate in the Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, and Wentao Yang, deputy director of Department of Thoracic Surgery, the Second Affiliated Hospital of Soochow University, for providing administrative support.
Dai C , Shen J , Ren Y , et al. . Choice of surgical procedure for patients with non-small-cell lung cancer ≤ 1 cm or > 1 to 2 cm among lobectomy, segmentectomy, and wedge resection: a population-based study. J Clin Oncol 2016;34:3175–3182.
National Lung Screening Trial Research Team. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011;365:395–409.
Wang L , Jiang W , Zhan C , et al. . Lymph node metastasis in clinical stage IA peripheral lung cancer. Lung Cancer 2015;90:41–46.
Hattori A , Suzuki K , Matsunaga T , et al. . Is limited resection appropriate for radiologically “solid” tumors in small lung cancers? Ann Thorac Surg 2012;94:212–215.
Cho S , Song IH , Yang HC , et al. . Predictive factors for node metastasis in patients with clinical stage I non-small cell lung cancer. Ann Thorac Surg 2013;96:239–245.
Lin YH , Chen CK , Hsieh CC , et al. . Lymphadenectomy is unnecessary for pure ground-glass opacity pulmonary nodules. J Clin Med 2020;9:672.
Liang W , He J , Shen Y , et al. . Impact of examined lymph node count on precise staging and long-term survival of resected non-small-cell lung cancer: a population study of the US SEER database and a Chinese multi-institutional registry. J Clin Oncol 2017;35:1162–1170.
- Search Google Scholar
- Export Citation
. Liang W He J Shen Y Impact of examined lymph node count on precise staging and long-term survival of resected non-small-cell lung cancer: a population study of the US SEER database and a Chinese multi-institutional registry. J Clin Oncol 2017; 35: 1162– 1170.
Dai J , Liu M , Yang Y , et al. . Optimal lymph node examination and adjuvant chemotherapy for stage I lung cancer. J Thorac Oncol 2019;14:1277–1285.
David EA , Cooke DT , Chen Y , et al. . Does lymph node count influence survival in surgically resected non-small cell lung cancer? Ann Thorac Surg 2017;103:226–235.
Samayoa AX , Pezzi TA , Pezzi CM , et al. . Rationale for a minimum number of lymph nodes removed with non-small cell lung cancer resection: correlating the number of nodes removed with survival in 98,970 patients. Ann Surg Oncol 2016;23(Suppl 5):1005–1011.
Bosch DE , Farjah F , Wood DE , et al. . Regional lymph node sampling in lung carcinoma: a single institutional and national database comparison. Hum Pathol 2018;75:55–62.
Zhong WZ , Liu SY , Wu YL . Numbers or stations: from systematic sampling to individualized lymph node dissection in non-small-cell lung cancer. J Clin Oncol 2017;35:1143–1145.
Adachi H , Sakamaki K , Nishii T , et al. . Lobe-specific lymph node dissection as a standard procedure in surgery for non-small cell lung cancer: a propensity score matching study. J Thorac Oncol 2017;12:85–93.
Rusch VW , Asamura H , Watanabe H , et al. . The IASLC Lung Cancer Staging Project: a proposal for a new international lymph node map in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol 2009;4:568–577.
Hishida T , Miyaoka E , Yokoi K , et al. . Lobe-specific nodal dissection for clinical stage I and II NSCLC: Japanese multi-institutional retrospective study using a propensity score analysis. J Thorac Oncol 2016;11:1529–1537.
Shapiro M , Kadakia S , Lim J , et al. . Lobe-specific mediastinal nodal dissection is sufficient during lobectomy by video-assisted thoracic surgery or thoracotomy for early-stage lung cancer. Chest 2013;144:1615–1621.
Hattori A , Suzuki K , Maeyashiki T , et al. . The presence of air bronchogram is a novel predictor of negative nodal involvement in radiologically pure-solid lung cancer. Eur J Cardiothorac Surg 2014;45:699–702.
Goldstraw P , Chansky K , Crowley J , et al. . The IASLC Lung Cancer Staging Project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol 2016;11:39–51.
Li B , Cui Y , Diehn M , et al. . Development and validation of an individualized immune prognostic signature in early-stage nonsquamous non-small cell lung cancer. JAMA Oncol 2017;3:1529–1537.
Chen D , Song Y , Zhang F , et al. . Genome-wide analysis of lung adenocarcinoma identifies novel prognostic factors and a prognostic score. Front Genet 2019;10:493.
Song Y , Chen D , Zhang X , et al. . Integrating genetic mutations and expression profiles for survival prediction of lung adenocarcinoma. Thorac Cancer 2019;10:1220–1228.
Iyer RV , Hanlon A , Fowble B , et al. . Accuracy of the extent of axillary nodal positivity related to primary tumor size, number of involved nodes, and number of nodes examined. Int J Radiat Oncol Biol Phys 2000;47:1177–1183.
Groth SS , Virnig BA , Whitson BA , et al. . Determination of the minimum number of lymph nodes to examine to maximize survival in patients with esophageal carcinoma: data from the Surveillance Epidemiology and End Results database. J Thorac Cardiovasc Surg 2010;139:612–620.
- Search Google Scholar
- Export Citation
. Groth SS Virnig BA Whitson BA Determination of the minimum number of lymph nodes to examine to maximize survival in patients with esophageal carcinoma: data from the Surveillance Epidemiology and End Results database. J Thorac Cardiovasc Surg 2010; 139: 612– 620.
Hishida T , Saji H , Watanabe SI , et al. . A randomized phase III trial of lobe-specific vs. systematic nodal dissection for clinical stage I-II non-small cell lung cancer (JCOG1413). Jpn J Clin Oncol 2018;48:190–194.
Mao R , She Y , Zhu E , et al. . A proposal for restaging of invasive lung adenocarcinoma manifesting as pure ground glass opacity. Ann Thorac Surg 2019;107:1523–1531.
Zheng H , Wang LM , Bao F , et al. . Re-appraisal of N2 disease by lymphatic drainage pattern for non-small-cell lung cancers: by terms of nodal stations, zones, chains, and a composite. Lung Cancer 2011;74:497–503.
Riquet M , Rivera C , Pricopi C , et al. . Is the lymphatic drainage of lung cancer lobe-specific? A surgical appraisal. Eur J Cardiothorac Surg 2015;47:543–549.
Liang RB , Yang J , Zeng TS , et al. . Incidence and distribution of lobe-specific mediastinal lymph node metastasis in non-small cell lung cancer: data from 4511 resected cases. Ann Surg Oncol 2018;25:3300–3307.
Riquet M , Legras A , Mordant P , et al. . Number of mediastinal lymph nodes in non-small cell lung cancer: a Gaussian curve, not a prognostic factor. Ann Thorac Surg 2014;98:224–231.