An estimated 300,000 people in the United States are currently living with a myeloproliferative neoplasm (MPN), a heterogeneous group of hematopoietic stem cell diseases, characterized by activated JAK/STAT signaling and a propensity for evolution to myeloid blast-phase disease. At the NCCN 2021 Virtual Congress: Hematologic Malignancies, Aaron T. Gerds, MD, MS, Associate Professor of Medicine and Deputy Director for Clinical Research, Cleveland Clinic Taussig Cancer Institute, and Medical Director, Case Comprehensive Cancer Center Clinical Research Office, discussed the importance of mutations in the diagnosis, prognosis, and treatment of patients with MPNs. “We are living in the age of molecular analysis and molecular biology,” said Dr. Gerds. “It is critically important to understand how and why these mutations occur so we can apply this knowledge to our everyday clinics and develop new therapeutics for the future.”
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, Passamonti F , Cervantes F , Vannucchi AM A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood 2010; 115: 1703– 1708. 10.1182/blood-2009-09-245837
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