Introduction: Early death due to cancer results in lost societal productivity and is an important contributor to the overall burden of the disease. The objective of this study was to examine trends in years of potential life lost (YoPLL) due to cervical and uterine cancer in the United States between 2000 and 2016. Methods: YoPLL due to cervical and uterine cancer in each year was calculated by summing, for each death, the remaining life expectancy at the age of death. The number of deaths by age due to each cancer type and remaining life expectancy by age were obtained from the World Health Organization (WHO) Mortality Database and Life Tables, respectively. YoPLL is presented as the sum across all deaths due to cervical or uterine cancer in the US each year, and as the average YoPLL per death, calculated as the total YoPLL divided by the number of deaths in each year. Results: The number of cervical cancer deaths per year was relatively stable during the study period, lowest in 2004 (3,847 deaths) and highest in 2016 (4,419 deaths). Total YoPLL and average YoPLL per death followed a similar pattern, ranging from 107,600 to 117,590 YoPLL per year (Figure) and 26.5 to 28.7 YoPLL per death. Conversely, the number of uterine cancer deaths per year increased from 6,570 in the year 2000 to 10,713 in 2016, and total YoPLL increased from 110,266 to 207,684 (Figure). The average YoPLL per uterine cancer death increased from 16.8 in 2000 to 19.4 in 2016. Conclusions: YoPLL is a measure of the societal burden of early death and is a key component of the global burden of cancer. Between 2000 and 2016, YoPLL due to uterine cancer nearly doubled, while YoPLL due to cervical cancer remained stable.