Precision medicine has rapidly been applied by oncologists who treat non–small cell lung cancer (NSCLC). In patients with newly diagnosed advanced-stage NSCLC, it is now considered standard of care to offer treatment regimens based on molecular status, but the implications of de novo T790M are not yet widely known. When multiple biopsies show T790M mutations, suspicion of and testing for germline T790M mutations are crucial in providing precise and tailored management for patients with NSCLC and their potentially affected family members.
The authors have disclosed that they have no financial interests, arrangements, affiliations, or commercial interests with the manufacturers of any products discussed in this article or their competitors.
The preliminary result of this study was accepted for a poster presentation at the 2017 Multidisciplinary Thoracic Cancer Symposium; March 16–18, 2017; San Francisco, California.
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