Dr. Collisson has disclosed that he receives support from the Doris Duke Charitable Foundation and the V Foundation Rombauer Fellowship; he also receives consulting fees from Guardant Health. Dr. Taylor has disclosed that his work is supported in part by the Prostate Cancer Foundation and the Sontag Foundation. The remaining authors have disclosed that they have no financial interests, arrangements, affiliations, or commercial interests with the manufacturers of any products discussed in this article or their competitors.
Deborah J. Moonan, RN, BSN, Director, Continuing Education, has disclosed that she has no relevant financial relationships.
Ann Gianola, MA, Manager, Continuing Education Accreditation & Program Operations, has disclosed that she has no relevant financial relationships.
Kristina M. Gregory, RN, MSN, OCN, Vice President, Clinical Information Operations, has disclosed that she has no relevant financial relationships.
Rashmi Kumar, PhD, Senior Manager, Clinical Content, has disclosed that she has no relevant financial relationships.
Susan D. Darlow, PhD, Oncology Scientist/Medical Writer, has disclosed that she has no relevant financial relationships.
The authors are grateful to D. Rodriguez-Jaquez for her assistance throughout this work; J. Chmielecki, D. Lipson, and A. Talasaz for data sharing and access; and N. Schultz for critical reading of this manuscript.
Detailed Clinical Timeline.
Compendium of tumors used for comparative genomic analysis. For Figure 2B we used publically available data from 9122 primary tumors to assess the frequency of genetic abnormalities seen in our index case across cancer. Much of these data have been published and abbreviated references are included next to the cohort's name, where available. All cohorts who had at least one tumor with one of our patient's 5 genetic abnormalities (focal genomic amplifications of MYC, CCND3, and SOX2 or mutations in DNMT3A, and BRCA2) were included.
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