Dr. Johnson has disclosed that he received research support from grant K12 CA 0906525. He has disclosed no other financial interests, arrangements, affiliations, or commercial interests with the manufacturers of any products discussed in this article or their competitors. Dr. Sosman has disclosed that he is on the advisory board for Bristol-Myers Squibb Company and Genentech, Inc.
Kerrin M. Green, MA, Assistant Managing Editor, JNCCN—Journal of the National Comprehensive Cancer Network
Ms. Green has disclosed that she has no relevant financial relationships.
Deborah J. Moonan, RN, BSN, Director, Continuing Education & Grants Ms. Moonan has disclosed that she has no relevant financial relationships.
Ann Gianola, MA, Manager, Continuing Education & Grants
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Kristina M. Gregory, RN, MSN, OCN, Vice President, Clinical Information Operations
Ms. Gregory has disclosed that she has no relevant financial relationships.
Lovly CM, Dahlman KB, Fohn LE et al.. Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials. PLoS One 2012;7:e35309.
Chapman PB, Hauschild A, Robert C et al.. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011;364:2507–2516.
Sosman JA, Kim KB, Schuchter L et al.. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med 2012;366:707–714.
Hauschild A, Grob JJ, Demidov LV et al.. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 2012;380:358–365.
Flaherty KT, Robert C, Hersey P et al.. Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl J Med 2012;367:107–114.
Flaherty KT, Infante JR, Daud A et al.. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012;367:1694–1703.
Hodi FS, O’Day SJ, McDermott DF et al.. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363:711–723.
Rosenberg SA, Yang JC, Topalian SL et al.. Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2. JAMA 1994;271:907–913.
Atkins MB, Lotze MT, Dutcher JP et al.. High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J Clin Oncol 1999;17:2105–2116.
Prieto PA, Yang JC, Sherry RM et al.. CTLA-4 blockade with ipilimumab: long-term follow-up of 177 patients with metastatic melanoma. Clin Cancer Res 2012;18:2039–2047.
Ackerman A, Klein O, McDermott DF et al.. Outcomes of patients with metastatic melanoma treated with immunotherapy prior to or after BRAF inhibitors. Cancer, in press.
Ascierto PA, Simeone E, Giannarelli D et al.. Sequencing of BRAF inhibitors and ipilimumab in patients with metastatic melanoma: a possible algorithm for clinical use. J Transl Med 2012;10:107.
Topalian SL, Hodi FS, Brahmer JR et al.. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366:2443–2454.
Hamid O, Robert C, Daud A et al.. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013;369:134–144.
MacGee W. Metastatic and invasive tumours involving the heart in a geriatric population: a necropsy study. Virchows Arch A Pathol Anat Histopathol 1991;419:183–189.
de Vasconcelos VT, Arias VE, Ikeda S. Cardiac metastasis of melanoma presenting as acute aortic occlusion. J Thromb Thrombolysis 2013;36:536–538..
Auer J, Schmid J, Berent R et al.. Cardiac metastasis of malignant melanoma mimicking acute coronary syndrome. Eur Heart J 2012;33:676.
Cheng G, Newberg AB, Alavi A. Metastatic melanoma causing complete atrioventricular block--the role of FDG PET/CT in diagnosis. Clin Imaging 2011;35:312–314.
Kontozis L, Soteriou M, Papamichael D et al.. Isolated right atrial metastasis of malignant melanoma mimicking a myxoma. Hellenic J Cardiol 2011;52:281–284.
Leja MJ, Kim M, Perryman L et al.. Metastatic melanoma to the intracavitary left ventricle treated using cardiac autotransplantation technique for resection. Methodist Debakey Cardiovasc J 2011;7:44–46.
Magnuson WJ, Halligan JB. Successful treatment of melanoma metastatic to the left atrium using external beam radiation therapy. Oncology (Williston Park) 2010;24:650–653.