Bile duct transmission is the keynote feature of photodynamic therapy (PDT) and is unique to the gastrointestinal tract, declared Michel Kahaleh, MD, Chief of Endoscopy at Weill Cornell Medical College in New York City. Its ability to reach unreachable or peripheral lesions makes it an attractive palliative alternative for managing patients with cholangiocarcinoma, he added. Most cholangiocarcinomas are unresectable, and biliary decompression is the major objective. Based on the findings of many studies, both past and present, PDT seems to be an effective way to improve the quality of life of patients with cholangiocarcinoma, with randomized controlled trials needed to also confirm its promise in prolonging survival.
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. Pereira S Hughes SK Roughton M Photostent-02: porfimer sodium photodynamic therapy plus stenting versus stenting alone in patients with advanced or metastatic cholangiocarcinomas and other biliary tract tumours: a multicentre, randomised phase III trial [abstract]. Presented at the European Society for Medical Oncology (ESMO) 2010 Congress; October 8–12, 2010; Milan, Italy. Abstract 802O.
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