“We can use photodynamic therapy [PDT] to cure a lot of primary tumors, but what about its ability to enhance antitumor immunity?” This question was explored in detail by Sandra O. Gollnick, PhD, of the PDT Center, Department of Cell Stress Biology at Roswell Park Cancer Institute, Buffalo, New York, an immunologist with years of laboratory expertise with PDT. From laboratory findings in mice models to preliminary results in tumor cells in patients, the increased antitumor immune response achieved after PDT continues to be explored. Preclinical mice studies have suggested that through augmenting T-cell proliferation, tumor-infiltrating neutrophils may play a key role in establishing PDT-enhanced antitumor immunity.1 A clearer understanding of the mechanisms of action regarding this enhancement in antitumor immune response with PDT represents the first step on the road to establishing a new treatment strategy that takes advantage of this phenomenon, which requires further testing in clinical trials.
Kousis PC, Henderson BW, Maier PG, Gollnick SO. Photodynamic therapy enhancement of antitumor immunity is regulated by neutrophils. Cancer Res 2007;67:10501–10510.
Kabingu E, Oseroff AR, Wilding GE, Gollnick SW. Enhanced systemic immune reactivity to a basal cell carcinoma associated antigen following photodynamic therapy. Clin Cancer Res 2009;15:4460–4466.
Gollnick SO, Liu X, Owczarczak B. Altered expression of interleukin 6 and interleukin 10 as a result of photodynamic therapy in vivo. Cancer Res 1997;57:3904–3909.
Usuda J, Okunaka T, Turukawa K. Increased cytotoxic effects of photodynamic therapy in IL-6 gene transfected cells via enhanced apoptosis. Int J Cancer 2001;93:475–480.
Henderson BW, Gollnick SO, Snyder JW. Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors. Cancer Res 2004;64:2120–2126.
Gollnick SO, Vaughan L, Henderson BW. Generation of effective antitumor vaccines using photodynamic therapy. Cancer Res 2002;62:1604–1608.