“The interplay between the laboratory and the clinic will be very important as we go forward,” predicted Keith Cengel, MD, PhD, of the Department of Radiation Oncology at the University of Pennsylvania School of Medicine in Philadelphia. With one foot in the research arena and the other in the surgical suite, Dr. Cengel offered a unique perspective on the challenges involved in testing preclinical ideas and then refining them as needed for optimal use in patients. After discussing the issues involved in adapting pleural photodynamic therapy (PDT) to follow surgery, Dr. Cengel addressed the difficulties of measuring fluorescence and photosensitizer concentrations, described the road from the bench to the clinic and often back to the bench to improve models and explore new pathways, and outlined the modifications in interstitial PDT for prostate and head and neck cancers being investigated in early-stage clinical trials.
Wang HW, Rickter E, Yuan M et al.. Effect of photosensitizer dose on fluence rate responses to photodynamic therapy. Photochem Photobiol 2007;83:1040–1048.
Gryshuk AL, Graham A, Pandey SK et al.. A first comparative study of purpurinimide-based fluorinated vs nonfluorinated photosensitizers for photodynamic therapy. Photochem Photobiol 2002;76:555–559.
Yu G, Durduran T, Zhou C et al.. Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy. Clin Cancer Res 2005;11:3543–3552.
Onn A, Isobe T, Itasaka S et al.. Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice. Clin Cancer Res 2003;9:5532–5539.
Grossman CE, Pickup S, Durham A et al.. Photodynamic therapy of disseminated non-small cell lung carcinoma in a murine model. Lasers Surg Med 2011;43:663–675.
Patel H, Mick R, Finlay J et al.. Motexafin lutetium-photodynamic therapy of prostate cancer: short- and long-term effects on prostate-specific antigen. Clin Cancer Res 2008;14:4869–4876.
Quon H, Finlay J, Cengel K et al.. Transoral robotic photodynamic therapy for the oropharynx. Photodiagnosis Photodyn Ther 2011;8:64–67.