“The interplay between the laboratory and the clinic will be very important as we go forward,” predicted Keith Cengel, MD, PhD, of the Department of Radiation Oncology at the University of Pennsylvania School of Medicine in Philadelphia. With one foot in the research arena and the other in the surgical suite, Dr. Cengel offered a unique perspective on the challenges involved in testing preclinical ideas and then refining them as needed for optimal use in patients. After discussing the issues involved in adapting pleural photodynamic therapy (PDT) to follow surgery, Dr. Cengel addressed the difficulties of measuring fluorescence and photosensitizer concentrations, described the road from the bench to the clinic and often back to the bench to improve models and explore new pathways, and outlined the modifications in interstitial PDT for prostate and head and neck cancers being investigated in early-stage clinical trials.
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