New Agents in Chronic Myelogenous Leukemia

Authors:
Jorge CortesFrom the Department of Leukemia, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas.

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Francis GilesFrom the Department of Leukemia, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas.

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Volume/Issue:
Volume 1: Issue 4
Online Publication Date:
Nov 2003
DOI:
https://doi.org/10.6004/jnccn.2003.0042
Full access

Multiple new agents are currently being developed in chronic myelogenous leukemia (CML). Most of these agents are now being investigated in patients who have developed resistance to imatinib. Their mechanisms of action are diverse and many may be synergistic with imatinib. These agents will be used soon in different combinations, most likely including imatinib, with the hope of obtaining a complete blockade of the intracellular pathways that are triggered by Bcr-Abl. If this is successful, complete eradication of disease may become a reality for the majority of patients with CML.

Jorge Cortes has research grant support from Novartis, Schering-Plough, Jensen, and Millennium.

Correspondence: Jorge Cortes, MD, 1515 Holcombe, Blvd, Unit 428, Houston, TX 77030. E-mail: jcortes@mdanderson.org
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Copyright:
Copyright © 2003 by the National Comprehensive Cancer Network 2003
Page Numbers:
12
Article Category:
Research Article
Received:
14 Jul 2003
Accepted:
11 Aug 2003
Print Publication Date:
01 Nov 2003
Online Publication Date:
Nov 2003
Keywords:
Chronic myelogenous leukemia; chemotherapy; new agents; imatinib; bcr-abl; intracellular pathways
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