that most but not all carcinosarcomas of the uterus are combination tumors . Cancer Res 1997 ; 57 : 5379 – 5385 . 3 Abeln EC Smit VT Wessels JW . Molecular genetic evidence for the conversion hypothesis of the origin of malignant mixed
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Lauren E. Kernochan and Rochelle L. Garcia
Edited by Kerrin G. Robinson
Anisley Valenciaga, O. Hans Iwenofu, and Gabriel Tinoco
iatrogenic displacement. 5 Pleomorphic liposarcoma of the uterus (PLU) is therefore an extremely rare disease. It is composed of smooth muscle, mature adipocytes, and lipoblasts. 6 PLU presents most commonly in postmenopausal women and has a poor
Wui-Jin Koh, Nadeem R. Abu-Rustum, Sarah Bean, Kristin Bradley, Susana M. Campos, Kathleen R. Cho, Hye Sook Chon, Christina Chu, David Cohn, Marta Ann Crispens, Shari Damast, Oliver Dorigo, Patricia J. Eifel, Christine M. Fisher, Peter Frederick, David K. Gaffney, Suzanne George, Ernest Han, Susan Higgins, Warner K. Huh, John R. Lurain III, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Amanda Nickles Fader, Steven W. Remmenga, R. Kevin Reynolds, Todd Tillmanns, Stefanie Ueda, Emily Wyse, Catheryn M. Yashar, Nicole R. McMillian, and Jillian L. Scavone
recurrent endometrial carcinoma and uterine sarcoma. Endometrial Cancer In 2017, 67% of patients with adenocarcinoma of the endometrium were diagnosed with disease confined to the uterus at diagnosis. 1 Regional and distant disease comprised 21% and
Wui-Jin Koh, Benjamin E. Greer, Nadeem R. Abu-Rustum, Sachin M. Apte, Susana M. Campos, John Chan, Kathleen R. Cho, David Cohn, Marta Ann Crispens, Nefertiti DuPont, Patricia J. Eifel, David K. Gaffney, Robert L. Giuntoli II, Ernest Han, Warner K. Huh, John R. Lurain III, Lainie Martin, Mark A. Morgan, David Mutch, Steven W. Remmenga, R. Kevin Reynolds, William Small Jr, Nelson Teng, Todd Tillmanns, Fidel A. Valea, Nicole R. McMillian, and Miranda Hughes
in Oncology (NCCN Guidelines) focuses on early-stage disease (ie, disease confined to the uterus), because it occurs more frequently ( http://seer.cancer.gov/statfacts/html/cervix.html ). The guideline includes fertility-sparing and non
Rowan T. Chlebowski, Aaron K. Aragaki, and Garnet L. Anderson
beginning in 1975, 2 , 3 the addition of progestin to reduce this risk became standard for women with an intact uterus. Shortly thereafter in 1976, the identification of an increased breast cancer risk associated with menopausal hormone therapy also raised
Harold J. Burstein
, colorectal, melanoma, pancreas, lymphoma, bladder, uterus), fewer than 10% of all recommendations were level 1. The most level 1 recommendations were in initial therapy; beyond that, the rate drops substantially. These observations point to a large gap in
Christopher Loiselle and Wui-Jin Koh
characterize motion of the uterus and cervix. 29 One dosimetric study found that margins of 4 cm at the fundus and 1.5 cm at the cervical os were necessary to encompass 90% of interscan motion. 30 Another article suggested that 2-cm PTV expansions led
Nadeem R. Abu-Rustum
these women will present with early-stage disease (90%), without metastasis, 8 limiting the amount of deaths to approximately 8190 per year. 7 Because most of these tumors will be confined to the uterus (International Federation of Gynecology and
Robert L. Coleman, Michael Frumovitz, and Charles F. Levenback
Godard H . Les lymphatiques de l'uterus . Rev Chir 1923 : 61 ; 219 – 248 . [ in French ] 4. Morton DL Thompson JF Essner R . Validation of the accuracy of intraoperative lymphatic mapping and sentinel lymphadenectomy for early
Thai H. Ho and Eric Jonasch
. Affected persons are at increased risk for tumor development of skin, uterus, and kidney. Abbreviation: RCC, renal cell carcinoma. RCC may be the only clinical presentation in persons with germline SDHB, SDHC , or SDHD mutations. 2 Extrarenal