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Lauren E. Kernochan and Rochelle L. Garcia

Edited by Kerrin G. Robinson

that most but not all carcinosarcomas of the uterus are combination tumors . Cancer Res 1997 ; 57 : 5379 – 5385 . 3 Abeln EC Smit VT Wessels JW . Molecular genetic evidence for the conversion hypothesis of the origin of malignant mixed

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Anisley Valenciaga, O. Hans Iwenofu, and Gabriel Tinoco

iatrogenic displacement. 5 Pleomorphic liposarcoma of the uterus (PLU) is therefore an extremely rare disease. It is composed of smooth muscle, mature adipocytes, and lipoblasts. 6 PLU presents most commonly in postmenopausal women and has a poor

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Wui-Jin Koh, Nadeem R. Abu-Rustum, Sarah Bean, Kristin Bradley, Susana M. Campos, Kathleen R. Cho, Hye Sook Chon, Christina Chu, David Cohn, Marta Ann Crispens, Shari Damast, Oliver Dorigo, Patricia J. Eifel, Christine M. Fisher, Peter Frederick, David K. Gaffney, Suzanne George, Ernest Han, Susan Higgins, Warner K. Huh, John R. Lurain III, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Amanda Nickles Fader, Steven W. Remmenga, R. Kevin Reynolds, Todd Tillmanns, Stefanie Ueda, Emily Wyse, Catheryn M. Yashar, Nicole R. McMillian, and Jillian L. Scavone

recurrent endometrial carcinoma and uterine sarcoma. Endometrial Cancer In 2017, 67% of patients with adenocarcinoma of the endometrium were diagnosed with disease confined to the uterus at diagnosis. 1 Regional and distant disease comprised 21% and

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Wui-Jin Koh, Benjamin E. Greer, Nadeem R. Abu-Rustum, Sachin M. Apte, Susana M. Campos, John Chan, Kathleen R. Cho, David Cohn, Marta Ann Crispens, Nefertiti DuPont, Patricia J. Eifel, David K. Gaffney, Robert L. Giuntoli II, Ernest Han, Warner K. Huh, John R. Lurain III, Lainie Martin, Mark A. Morgan, David Mutch, Steven W. Remmenga, R. Kevin Reynolds, William Small Jr, Nelson Teng, Todd Tillmanns, Fidel A. Valea, Nicole R. McMillian, and Miranda Hughes

in Oncology (NCCN Guidelines) focuses on early-stage disease (ie, disease confined to the uterus), because it occurs more frequently ( http://seer.cancer.gov/statfacts/html/cervix.html ). The guideline includes fertility-sparing and non

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Rowan T. Chlebowski, Aaron K. Aragaki, and Garnet L. Anderson

beginning in 1975, 2 , 3 the addition of progestin to reduce this risk became standard for women with an intact uterus. Shortly thereafter in 1976, the identification of an increased breast cancer risk associated with menopausal hormone therapy also raised

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Harold J. Burstein

, colorectal, melanoma, pancreas, lymphoma, bladder, uterus), fewer than 10% of all recommendations were level 1. The most level 1 recommendations were in initial therapy; beyond that, the rate drops substantially. These observations point to a large gap in

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Christopher Loiselle and Wui-Jin Koh

characterize motion of the uterus and cervix. 29 One dosimetric study found that margins of 4 cm at the fundus and 1.5 cm at the cervical os were necessary to encompass 90% of interscan motion. 30 Another article suggested that 2-cm PTV expansions led

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Nadeem R. Abu-Rustum

these women will present with early-stage disease (90%), without metastasis, 8 limiting the amount of deaths to approximately 8190 per year. 7 Because most of these tumors will be confined to the uterus (International Federation of Gynecology and

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Robert L. Coleman, Michael Frumovitz, and Charles F. Levenback

Godard H . Les lymphatiques de l'uterus . Rev Chir 1923 : 61 ; 219 – 248 . [ in French ] 4. Morton DL Thompson JF Essner R . Validation of the accuracy of intraoperative lymphatic mapping and sentinel lymphadenectomy for early

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Thai H. Ho and Eric Jonasch

. Affected persons are at increased risk for tumor development of skin, uterus, and kidney. Abbreviation: RCC, renal cell carcinoma. RCC may be the only clinical presentation in persons with germline SDHB, SDHC , or SDHD mutations. 2 Extrarenal