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Merav Bar and Jerald Radich

Tyrosine Kinase Inhibitor Therapy for Chronic Myeloid Leukemia, 2012 Before the introduction of the tyrosine kinase inhibitors (TKIs), allogeneic hematopoietic cell transplantation (HCT) was the only “curative” approach for chronic myeloid

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Jerald P. Radich

Conference, Dr. Radich took stock of CML in 2013, noting improvements that include multiple tyrosine kinase inhibitors (TKIs) and sensitive measures of disease burden and thus response to therapy. Transplant also remains an effective salvage regimen that is

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Susan O'Brien, Ellin Berman, Joseph O. Moore, Javier Pinilla-Ibarz, Jerald P. Radich, Paul J. Shami, B. Douglas Smith, David S. Snyder, Hema M. Sundar, Moshe Talpaz, and Meir Wetzler

years, and eventually leads to terminal blast-phase disease, with death occurring from bleeding and infectious complications. 3 First-Line Treatment: Imatinib Versus Second-Generation Tyrosine Kinase Inhibitors Imatinib Imatinib is a selective inhibitor

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Helena A. Yu and Gregory J. Riely

. First-Generation EGFR Tyrosine Kinase Inhibitors Gefitinib and erlotinib were the first EGFR tyrosine kinase inhibitors (TKIs) that were approved for the treatment of patients with non–small cell lung cancer (NSCLC). These drugs inhibit kinase activity

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Jerald P. Radich and Vivian Oehler

leukemia patients ``late,'' 18 months or more after transplantation . Blood 2001 ; 98 : 1701 – 1707 . 14. Hughes T Deininger M Hochhaus A . Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and

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Rofieda R. Alwaqfi, Megan I. Samuelson, Natalya N. Guseva, Michelle Ouyang, Aaron D. Bossler, and Deqin Ma

multitarget tyrosine kinase inhibitor (TKI). A CT scan 2 months post pazopanib therapy showed significant response with necrotic liver lesions and resolved peritoneal nodules ( Figure 1D ). During pazopanib treatment, the patient developed severe headache and

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Noa Efrat Ben-Baruch, Ron Bose, Shyam M. Kavuri, Cynthia X. Ma, and Matthew J. Ellis

metastatic breast cancer for HER2 mutations, and treating patients with HER2-positive breast cancer with the second-generation HER2/EGFR tyrosine kinase inhibitor neratinib (HKI-272) ( ClinicalTrials.gov identifiers: NCT01670877 and NCT01953926). This

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Henry J. Henk, Lena E. Winestone, Jennifer J. Wilkes, Laura Becker, Pamela Morin, Gary H. Lyman, and Eric J. Chow

Background: Chronic myeloid leukemia (CML) treatment improved considerably after introduction of oral tyrosine kinase inhibitors (TKI). As a result, the number of patients living with CML may reach 250,000 by 2040. We track changes in TKI treatment

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Stephen Harnicar

has not been determined. In addition to high-dose imatinib, patients now have more options for front-line therapy with the introduction of the second-generation tyrosine kinase inhibitors (TKIs). Originally approved for imatinib failure or

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Jerald P. Radich

use of tyrosine kinase inhibitors (TKIs), survival in blast crisis has not clearly improved with these targeted agents. Progression to blast crisis in CML is a phenomenon that is still not completely understood. Although definitions of both