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Trastuzumab-Related Cardiac Dysfunction

Melinda L. Telli and Ronald M. Witteles

. Important recent data documenting the occurrence and prognostic utility of cardiac troponin I elevations among patients treated with trastuzumab will be placed into context with the mechanistic insight this data provides and the implications it carries for

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Risk Factors for the Assessment of Patients with Pulmonary Embolism

John Fanikos and Samuel Z. Goldhaber

. Independent prognostic value of cardiac troponin T in patients with confirmed pulmonary embolism . Circulation 2000 ; 102 : 211 – 217 . 37. Konstantinides S Geibel A Olschewski M . Importance of cardiac troponins I and T in risk stratification

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Managing Systemic Light-Chain Amyloidosis

Raymond L. Comenzo

of the serum free light chain assay (FLC), clonal Ig V L gene identification and troponin I levels in a phase II trial of risk-adapted intravenous melphalan with adjuvant thalidomide and dexamethasone for newly diagnosed untreated patients with

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Systemic Light Chain Amyloidosis, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology

Shaji K. Kumar, Natalie S. Callander, Kehinde Adekola, Larry D. Anderson Jr., Muhamed Baljevic, Erica Campagnaro, Jorge J. Castillo, Caitlin Costello, Christopher D’Angelo, Srinivas Devarakonda, Noura Elsedawy, Alfred Garfall, Kelly Godby, Jens Hillengass, Leona Holmberg, Myo Htut, Carol Ann Huff, Malin Hultcrantz, Yubin Kang, Sarah Larson, Hans C. Lee, Michaela Liedtke, Thomas Martin, James Omel, Aaron Rosenberg, Douglas Sborov, Jason Valent, Ryan Berardi, and Rashmi Kumar

the serum provide a quantitative assessment of cardiac dysfunction (troponin I or T), and cardiac stress brain natriuretic peptide (BNP) or N -terminal prohormone of brain natriuretic peptide (NT-proBNP) are important predictors of outcome in

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Risk Stratification for Acute Pulmonary Embolism

Jeffrey A. Kline and David W. Miller

. 42 - 44 Troponin I and T, BNP, and NT-proBNP are the most extensively studied biomarkers for risk stratifying patients with acute PE. Several high-quality meta-analyses have quantized biomarkers' association with adverse outcome. 45 - 48 As shown

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Individualized Approach to Management of Light Chain Amyloidosis

Giovanni Palladini and Paolo Milani

In patients with stage IIIb AL amyloidosis, defined as having elevated cardiac troponin (I >100 ng/L or T >35 ng/L or high-sensitivity troponin T>45 ng/L) and a concentration of N -terminal pro–type-B natriuretic peptide (NT-proBNP) >8,500 ng/L (or

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Survivorship, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

Crystal S. Denlinger, Tara Sanft, K. Scott Baker, Gregory Broderick, Wendy Demark-Wahnefried, Debra L. Friedman, Mindy Goldman, Melissa Hudson, Nazanin Khakpour, Allison King, Divya Koura, Robin M. Lally, Terry S. Langbaum, Allison L. McDonough, Michelle Melisko, Jose G. Montoya, Kathi Mooney, Javid J. Moslehi, Tracey O'Connor, Linda Overholser, Electra D. Paskett, Jeffrey Peppercorn, William Pirl, M. Alma Rodriguez, Kathryn J. Ruddy, Paula Silverman, Sophia Smith, Karen L. Syrjala, Amye Tevaarwerk, Susan G. Urba, Mark T. Wakabayashi, Phyllis Zee, Nicole R. McMillian, and Deborah A. Freedman-Cass

platform remains to be determined. In addition, the sensitivity and specificity of troponin I levels for predicting cardiotoxicity are fairly low, reported at 48% (95% CI, 0.27–0.69) and 73% (95% CI, 0.59–0.84), respectively. 61 A systematic review of the

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Venous Thromboembolic Disease

Michael B. Streiff, Paula L. Bockenstedt, Spero R. Cataland, Carolyn Chesney, Charles Eby, John Fanikos, Patrick F. Fogarty, Shuwei Gao, Julio Garcia-Aguilar, Samuel Z. Goldhaber, Hani Hassoun, Paul Hendrie, Bjorn Holmstrom, Kimberly A. Jones, Nicole Kuderer, Jason T. Lee, Michael M. Millenson, Anne T. Neff, Thomas L. Ortel, Judy L. Smith, Gary C. Yee, and Anaadriana Zakarija

meta-analysis . Circulation 2007 ; 116 : 427 - 433 . 144 Konstantinides S Geibel A Olschewski M . Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism . Circulation 2002 ; 106 : 1263