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Jeffrey F. Moley

is helpful in screening patients who are at risk for MTC and in following up those who have been treated. After thyroidectomy for MTC, elevated blood levels of calcitonin indicate persistent regional nodal metastasis or distant metastasis. 6 – 8 Some

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R. Michael Tuttle, Douglas W. Ball, David Byrd, Gilbert H. Daniels, Raza A. Dilawari, Gerard M. Doherty, Quan-Yang Duh, Hormoz Ehya, William B. Farrar, Robert I. Haddad, Fouad Kandeel, Richard T. Kloos, Peter Kopp, Dominick M. Lamonica, Thom R. Loree, William M. Lydiatt, Judith McCaffrey, John A. Olson Jr., Lee Parks, John A. Ridge, Jatin P. Shah, Steven I. Sherman, Cord Sturgeon, Steven G. Waguespack, Thomas N. Wang, and Lori J. Wirth

nodule (see page 515). Reports suggest that approximately 3% of patients with nodular thyroid disease will have an increased serum calcitonin level when measured with a sensitive immunometric assay; 40% of these patients will have MTC at thyroidectomy. 29

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R. Michael Tuttle, Douglas W. Ball, David Byrd, Raza A. Dilawari, Gerard M. Doherty, Quan-Yang Duh, Hormoz Ehya, William B. Farrar, Robert I. Haddad, Fouad Kandeel, Richard T. Kloos, Peter Kopp, Dominick M. Lamonica, Thom R. Loree, William M. Lydiatt, Judith C. McCaffrey, John A. Olson Jr., Lee Parks, John A. Ridge, Jatin P. Shah, Steven I. Sherman, Cord Sturgeon, Steven G. Waguespack, Thomas N. Wang, and Lori J. Wirth

. Before thyroidectomy is performed, however, serum TSH level and thyroid 123 I or 99m technetium scanning may identify patients with an autonomously functioning or “hot” nodule who often may be spared surgery, because the diagnosis of follicular adenoma

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Stephanie A. Terezakis and Nancy Y. Lee

. Furthermore, MTC is frequently multifocal, particularly in the hereditary form, but can also be multifocal in the sporadic form in approximately 20% of patients. Early prophylactic thyroidectomy is routinely performed in patients with MEN 2 with RET proto

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Maria A. Kouvaraki, Suzanne E. Shapiro, Jeffrey E. Lee, Douglas B. Evans, and Nancy D. Perrier

: 958 – 964 ; discussion 964–956 . 44 Cady B Sedgwick CE Meissner WA . Risk factor analysis in differentiated thyroid cancer . Cancer 1979 ; 43 : 810 – 820 . 45 Kebebew E Duh QY Clark OH . Total thyroidectomy or thyroid

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Jennifer B. Ogilvie and Electron Kebebew

thyroid carcinoma: the need for early diagnosis and total thyroidectomy . Arch Surg 1989 ; 124 : 1206 – 1210 . 58. Skinner MA DeBenedetti MK Moley JF . Medullary thyroid carcinoma in children with multiplel endocrine Neoplasia types 2A and 2

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Ashwaq Mohammed Alanazi, Rawan Alshalhoub, Maha Meshal Alrasheed, Nora Abanamy, Dana Bakheet, and Nduna Dzimiri

Background: Patients with differentiated thyroid cancer (DTC) are usually managed with total thyroidectomy and subsequent radioiodine ablation of the remnant thyroid tissue. L-thyroxine (L-T4) therapy (about 2 µg/kg) is required for life, with a

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Stephanie L. Lee

thyroid pain occurs 3 to 7 days after RAI therapy. Generally, this risk is very low after near-total or total thyroidectomy without extensive neck metastases. 38 A painless swelling of the neck has been described that occurs within 48 hours after the

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Steven G. Waguespack and Gary Francis

-term mortality. Preoperative staging helps identify children who do not have cervical lymph node involvement and thus have a reduced risk of distant metastases and recurrence. These children can generally be treated with total thyroidectomy and close follow

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Arkadiusz Spychala, Michal Oko, Olga Zając-Spychala, and Witold Kycler

stress level. Patients and Methods: From October 2017 till September 2018, 41 patients aged 26–69 (median, 42) years referred for curative thyroidectomy were included into the study. EORTC QLQ-INFO25 questionnaire was used to measure level of patients