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Gary R. Hudes, Michael A. Carducci, Toni K. Choueiri, Peg Esper, Eric Jonasch, Rashmi Kumar, Kim A. Margolin, M. Dror Michaelson, Robert J. Motzer, Roberto Pili, Susan Roethke, and Sandy Srinivas

proliferation and resistance to replication stress. These differences in VHL and HIF status and their downstream effects on tumor cell proliferation and stress response may provide molecular criteria for selecting tumor-specific targeted therapies, and led to

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Alan P. Venook, Maria E. Arcila, Al B. Benson III, Donald A. Berry, David Ross Camidge, Robert W. Carlson, Toni K. Choueiri, Valerie Guild, Gregory P. Kalemkerian, Razelle Kurzrock, Christine M. Lovly, Amy E. McKee, Robert J. Morgan, Anthony J. Olszanski, Mary W. Redman, Vered Stearns, Joan McClure, and Marian L. Birkeland

advanced- and early-stage treatment decision-making. Testing for HER2 and use of HER2-targeted therapy in patients who are HER2+ has become the standard of care. 9 – 13 Because genomic aberrations often do not segregate by organ of origin, reclassification

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Rishi Agarwal, Jiang Wang, Keith Wilson, William Barrett, and John C. Morris

placement of a gastrostomy tube. The resected lung specimen was sent for CGP, which identified BRAF V600E, TP53 V217G, and CBL C419W genetic alterations ( Figure 2 ). In the absence of an available clinical trial, targeted therapy was initiated

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Philip J. Saylor and M. Dror Michaelson

sarcomatoid renal cell carcinoma . J Urol 2002 ; 167 : 65 – 70 . 62 Golshayan AR George S Heng DY . Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy . J Clin Oncol 2009 ; 27 : 235

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Karen L. Reckamp

“There is a growing list of approved targets and therapies included in the 2018 NCCN Guidelines for Non–Small Cell Lung Cancer [NSCLC] as well as emerging targets. Why does this matter? Because targeted therapies improve survival,” said Karen L

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Tayyaba Hasan

tremendous chemoresistance, she explained. Well suited for superficial small-volume tumors, PDT is a mechanistically distinct alternative; it not only mitigates chemoresistance 4 but also synergizes with chemotherapy 4 , 5 and molecularly targeted therapies

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Rodger J. Winn

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Chadi Nabhan, Gregory Horner, and Michael D. Howell

. As oncology research and practice has evolved into molecular profiling of cancer and targeted therapy, we propose that Lean methodology is the targeted innovative approach to cancer care delivery. References 1. Schnipper LE Davidson NE

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Shira Dinner and Ranjana Advani

/print certificate. Release date: August 22, 2013; Expiration date: August 22, 2014 Learning Objectives Upon completion of this activity, participants will be able to: Describe the rationale for targeted therapy in patients with relapsed classical HL

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Daniel G. Coit, John A. Thompson, Mark R. Albertini, Christopher Barker, William E. Carson III, Carlo Contreras, Gregory A. Daniels, Dominick DiMaio, Ryan C. Fields, Martin D. Fleming, Morganna Freeman, Anjela Galan, Brian Gastman, Valerie Guild, Douglas Johnson, Richard W. Joseph, Julie R. Lange, Sameer Nath, Anthony J. Olszanski, Patrick Ott, Aparna Priyanath Gupta, Merrick I. Ross, April K. Salama, Joseph Skitzki, Jeffrey Sosman, Susan M. Swetter, Kenneth K. Tanabe, Evan Wuthrick, Nicole R. McMillian, and Anita M. Engh

recent meta-analysis reported improvements in 5- and 10-year event-free survival and OS of less than 4%. 18 IFN alfa has been supplanted, however, by targeted therapy and immune checkpoint inhibitor options based on results from recent and ongoing