in gastric cancer cell growth, angiogenesis, and vessel maturation . J Natl Cancer Inst 2004 ; 96 : 946 – 956 . 20 Dunst J Kuhnt T Strauss HG . Anemia in cervical cancers: impact on survival, patterns of relapse, and association with
Vishwajith Sridharan, Vinayak Muralidhar, Danielle N. Margalit, Roy B. Tishler, James A. DeCaprio, Manisha Thakuria, Guilherme Rabinowits and Jonathan D. Schoenfeld
carries a high risk of spreading to regional lymph nodes. Nodal recurrences and distant metastases are common, with limited survival for patients with advanced disease. 5 , 6 Treatment of localized MCC is variable, focusing on wide local excision
Nikolai A. Podoltsev, Mengxin Zhu, Amer M. Zeidan, Rong Wang, Xiaoyi Wang, Amy J. Davidoff, Scott F. Huntington, Smith Giri, Steven D. Gore and Xiaomei Ma
Background Essential thrombocythemia (ET) is a clonal myeloproliferative neoplasm (MPN) characterized by persistently elevated platelet counts. The median age at diagnosis is 68 years 1 and median survival is 19.8 years, which is inferior to that
Mei-Chin Hsieh, Lu Zhang, Xiao-Cheng Wu, Mary B. Davidson, Michelle Loch and Vivien W. Chen
, luminal B, basal-like (triple-negative: ER–/PR–/HER2–), and HER2+/ER–. 1 , 4 These subtypes vary by race and influence survival rate. 5 When physicians prescribe appropriate adjuvant systemic therapies (ASTs) for patients with breast cancer, molecular
Anuhya Kommalapati, Sri Harsha Tella, Adams Kusi Appiah, Lynette Smith and Apar Kishor Ganti
. The Intergroup 0139 study demonstrated an improvement in 5-year progression-free survival and local control with surgical resection after neoadjuvant chemoradiotherapy. 6 A trend toward improved overall survival (OS) was seen in the surgery group
Sujana Movva, Margaret von Mehren, Eric A. Ross and Elizabeth Handorf
Background Soft tissue sarcomas (STS) are uncommon tumors of the connective tissues. According to the current AJCC staging system, patients with stage III disease (large, deep, high-grade) have an expected overall survival (OS) of
Richard Li, Wei-Hsien Hou, Joseph Chao, Yanghee Woo, Scott Glaser, Arya Amini, Rebecca A. Nelson and Yi-Jen Chen
poor survival outcomes with CRT in the absence of curative surgery, although patients receiving CRT in these studies experienced significant treatment toxicity. 17 – 19 Both chemotherapy and radiation therapy (RT) techniques have advanced significantly
Zachary Veitch, Omar F. Khan, Derek Tilley, Patricia A. Tang, Domen Ribnikar, Douglas A. Stewart, Xanthoula Kostaras, Karen King and Sasha Lupichuk
Background Treatment of early-stage breast cancer with adjuvant chemotherapy has improved survival. Landmark meta-analyses by the Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) initially showed a 20% to 25% relative risk reduction in
Talia Golan, Tal Sella, Ofer Margalit, Uri Amit, Naama Halpern, Dan Aderka, Einat Shacham-Shmueli, Damien Urban and Yaacov Richard Lawrence
Background In recent years, substantial advances in the diagnosis and treatment of cancer have increased survival rates for most cancers. Despite this progress, death rates for pancreatic cancer (PDAC), the fourth-leading cause of cancer death
Amit G. Singal, Akbar K. Waljee, Nishant Patel, Emerson Y. Chen, Jasmin A. Tiro, Jorge A. Marrero and Adam C. Yopp
transplant, were excluded because of the lack of therapeutic options associated with a survival benefit. Similarly, patients with locally advanced (ie, tumor thrombus) or metastatic disease before 2008 were excluded given the lack of proven therapeutic
