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Nadeem R. Abu-Rustum

algorithm and use of “ultrastaging” Sentinel lymph node (SLN) mapping is an image-guided procedure that is well established in the treatment of cancers, such as melanoma 1 and breast cancer. 2 This approach is based on the concept that lymph drains in

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Robert H. I. Andtbacka and Jeffrey E. Gershenwald

patients: validation of the American Joint Committee on Cancer melanoma staging system . J Clin Oncol 2001 ; 19 : 3622 – 3634 . 5 Thompson JF Shaw HM . Is sentinel lymph node biopsy appropriate in patients with thin melanomas: too early to

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George Plitas and Charlotte E. Ariyan

melanoma has been guided by many multicenter randomized trials that have shaped management decisions. Treatment has evolved from elective lymph node dissections to newer strategies identifying the most at-risk patients through sentinel lymph node (SLN

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Hiram S. Cody III and Kimberly J. Van Zee

and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe . Surg Oncol 1993 ; 2 : 335 – 340 . 2 Giuliano AE Kirgan DM Guenther JM . Lymphatic mapping and sentinel lymphadenectomy for breast cancer . Ann Surg

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Daniel G. Coit and Anthony J. Olszanski

, and presence or absence of microsatellitosis (an indicator of stage III disease). Pure desmoplasia, if present, is important, as pure desmoplastic melanomas rarely metastasize to regional nodes, and sentinel lymph node biopsy may not be necessary. A

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Stephen B. Edge and David G. Sheldon

-DeMore N Tan LK Liberman L . Sentinel lymph node biopsy: Is it indicated in patients with high-risk ductal carcinoma-in-situ and ductal carcinoma-in-situ with microinvasion? Ann Surg Oncol 2000 ; 7 : 636 – 642 . 4 McMasters KM Chao C Wong SL

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James Sun, Brittany J. Mathias, Christine Laronga, Weihong Sun, Jun-Min Zhou, William J. Fulp, John V. Kiluk, and M. Catherine Lee

2 sentinel lymph nodes (SLNs). Both the American College of Surgeons Oncology Group (ACOSOG) Z0011 3 and IBCSB 23-01 trials 4 evaluated patients with early-stage breast cancer who had SLN micrometastases and randomized them to CLND versus

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Jennifer L. Schwartz, Sandra L. Wong, Scott A. McLean, James A. Hayman, Christopher D. Lao, Jeffrey H. Kozlow, Kelly M. Malloy, Carol R. Bradford, Marcus L. Frohm, Douglas R. Fullen, Lori Lowe, and Christopher K. Bichakjian

, sentinel lymph node biopsy (SLNB) has emerged as an important staging tool in patients without clinical evidence of metastases. 4 , 12 - 14 The 2010 AJCC staging system is the most recent consensus staging system for MCC, which incorporates sentinel lymph

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Anthony J. Olszanski

node; SLNB, sentinel lymph node biopsy; WLE, wide local excision. Data from Francken AB, Accortt NA, Shaw HM, et al. Follow-up schedules after treatment for malignant melanoma. Br J Surg 2008;95:1401–1407; Romano E, Scordo M, Dusza SW, et al. Site and

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Thanh H. Dellinger, Amy A. Hakim, Stephen J. Lee, Mark T. Wakabayashi, Robert J. Morgan, and Ernest S. Han

4 cm in size (stage IA, as well as small stage IB and II tumors that are ≤4 cm), a modified radical vulvectomy is indicated, together with surgical evaluation of the groin nodes. This can be accomplished with either sentinel lymph node (SLN) biopsies